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[肥胖与男性不育]

[Obesity and male infertility].

作者信息

Heráček J, Sobotka V, Urban M

机构信息

Univerzita Karlova v Praze, 3. lekarska fakulta, Urologicka klinika, Praha.

出版信息

Ceska Gynekol. 2012 Oct;77(5):450-6.

Abstract

The authors present a review on the effects of obesity on male fertility. Current scientific findings suggest an elevated risk of infertility among couples in which the male partner is obese. In obese men can be found reduced serum levels of androgens and SHBG and increased estrogen levels without compensatory increase in FSH. Among other impacts of male obesity that may contribute to increased risk of infertility are altered retention and metabolism of environmental toxins, lifestyle, sexual dysfunction, genetic factors, excessive secretion of hormones derived from adipose tissue, oxidative stress, sperm specific proteomic changes or elevated levels of cytokines. The increasing prevalence of obesity calls for greater clinical awareness of its impact on male fertility.

摘要

作者对肥胖对男性生育能力的影响进行了综述。目前的科学研究结果表明,男性伴侣肥胖的夫妇不孕风险升高。肥胖男性血清雄激素和性激素结合球蛋白水平降低,雌激素水平升高,而卵泡刺激素没有代偿性增加。男性肥胖可能导致不孕风险增加的其他影响包括环境毒素的潴留和代谢改变、生活方式、性功能障碍、遗传因素、脂肪组织衍生激素的过度分泌、氧化应激、精子特异性蛋白质组变化或细胞因子水平升高。肥胖患病率的不断上升要求临床更加关注其对男性生育能力的影响。

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