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1
Intravenous albumin infusion is an effective therapy for hyponatraemia in cirrhotic patients with ascites.静脉输注白蛋白是治疗肝硬化腹水患者低钠血症的有效方法。
Gut. 1990 Feb;31(2):204-7. doi: 10.1136/gut.31.2.204.
2
[Treatment of ascites in patients with liver cirrhosis without neither hyponatremia nor renal insufficiency. Results of a randomized study comparing diuretics and punctures compensated by albumin].[肝硬化无低钠血症及肾功能不全患者腹水的治疗。比较利尿剂与白蛋白补偿穿刺术的随机研究结果]
Gastroenterol Clin Biol. 1992;16(10):751-5.
3
Treatment of ascites in cirrhosis. Diuretics, peritoneovenous shunt, and large-volume paracentesis.肝硬化腹水的治疗。利尿剂、腹腔静脉分流术及大量腹腔穿刺放液术。
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4
Midodrine and albumin for prevention of complications in patients with cirrhosis awaiting liver transplantation. A randomized placebo-controlled trial.米多君和白蛋白预防肝硬化等待肝移植患者并发症的随机安慰剂对照试验。
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5
Effects of albumin infusion in cirrhotic patients.白蛋白输注对肝硬化患者的影响。
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6
[Paracentesis combined with albumin infusion in the treatment of tense ascites in cirrhotic patients].[腹腔穿刺术联合白蛋白输注治疗肝硬化患者的张力性腹水]
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7
Albumin infusion in liver cirrhotic patients.肝硬化患者的白蛋白输注
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Prevention of paracentesis-induced circulatory dysfunction in cirrhosis: standard vs half albumin doses. A prospective, randomized, unblinded pilot study.预防肝硬化腹水穿刺引起的循环功能障碍:标准剂量与半剂量白蛋白。一项前瞻性、随机、非盲的初步研究。
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Targeted Albumin Therapy Does Not Improve Short-Term Outcome in Hyponatremic Patients Hospitalized With Complications of Cirrhosis: Data From the ATTIRE Trial.靶向白蛋白治疗并未改善肝硬化并发症住院低钠血症患者的短期结局:来自 ATTIR 试验的数据。
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Albumin infusion in patients undergoing large-volume paracentesis: a meta-analysis of randomized trials.大量腹腔穿刺术患者输注白蛋白:随机试验的荟萃分析。
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1
Pharmacological Interventions for Cirrhotic Ascites: From Challenges to Emerging Therapeutic Horizons.肝硬化腹水的药物治疗:从挑战到新兴治疗领域。
Gut Liver. 2024 Nov 15;18(6):934-948. doi: 10.5009/gnl240038. Epub 2024 Aug 29.
2
Albumin: a comprehensive review and practical guideline for clinical use.白蛋白:临床应用的全面综述与实用指南。
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3
Controversies regarding albumin therapy in cirrhosis.关于肝硬化患者白蛋白治疗的争议。
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Daily Low-Volume Paracentesis and Clinical Complications in Patients With Refractory Ascites.每日小容量腹腔穿刺放液术与难治性腹水患者的临床并发症。
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Evidence-based hyponatremia management in liver disease.基于证据的肝脏疾病低钠血症管理。
Clin Mol Hepatol. 2023 Oct;29(4):924-944. doi: 10.3350/cmh.2023.0090. Epub 2023 Jun 5.
6
Asia-Pacific association for study of liver guidelines on management of ascites in liver disease.亚太肝脏研究协会肝病腹水管理指南
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Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway.低渗诱导通过 TRPV2 介导的 AKT-Bcl-2 通路诱导细胞凋亡抵抗。
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Use of Human Albumin Administration for the Prevention and Treatment of Hyponatremia in Patients with Liver Cirrhosis: A Systematic Review and Meta-Analysis.人血白蛋白在肝硬化患者低钠血症防治中的应用:一项系统评价和Meta分析
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9
Albumin administration in patients with cirrhosis: Current role and novel perspectives.肝硬化患者白蛋白治疗:当前作用与新视角。
World J Gastroenterol. 2022 Sep 7;28(33):4773-4786. doi: 10.3748/wjg.v28.i33.4773.
10
Clinical Implications, Evaluation, and Management of Hyponatremia in Cirrhosis.肝硬化患者低钠血症的临床意义、评估及管理
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本文引用的文献

1
An explanation for and experimental correction of the abnormal water diuresis in cirrhosis.肝硬化患者异常水利尿的解释及实验性纠正
J Clin Invest. 1960 Feb;39(2):248-61. doi: 10.1172/JCI104035.
2
RENAL EFFECTS OF ACUTE EXPANSION OF PLASMA VOLUME IN CIRRHOSIS.肝硬化时血浆容量急性扩充的肾脏效应
N Engl J Med. 1965 Feb 25;272:387-90. doi: 10.1056/NEJM196502252720802.
3
Effect of demeclocycline on renal function and urinary prostaglandin E2 and kallikrein in hyponatremic cirrhotics.去甲金霉素对低钠血症肝硬化患者肾功能、尿前列腺素E2和激肽释放酶的影响。
Nephron. 1984;36(1):30-7. doi: 10.1159/000183112.
4
Peritoneal dialysis in hyponatremia due to liver failure.肝衰竭所致低钠血症的腹膜透析
Scand J Gastroenterol. 1973;8(1):33-40.
5
Transection of the oesophagus for bleeding oesophageal varices.为治疗食管静脉曲张出血而行食管横断术。
Br J Surg. 1973 Aug;60(8):646-9. doi: 10.1002/bjs.1800600817.
6
Hypoalbuminaemic hyponatraemia: a new syndrome?低白蛋白血症性低钠血症:一种新综合征?
Br Med J (Clin Res Ed). 1985 Nov 2;291(6504):1253-5. doi: 10.1136/bmj.291.6504.1253.
7
Use of urea for treatment of water retention in hyponatraemic cirrhosis with ascites resistant to diuretics.使用尿素治疗对利尿剂耐药的低钠血症肝硬化腹水患者的水潴留。
Br Med J (Clin Res Ed). 1985 Jun 15;290(6484):1782-3. doi: 10.1136/bmj.290.6484.1782.
8
Derangements of renal water handling in liver disease.肝脏疾病时肾脏水代谢的紊乱
Gastroenterology. 1985 Dec;89(6):1415-25. doi: 10.1016/0016-5085(85)90664-x.
9
Correction of severe hyponatraemia by continuous arteriovenous haemofiltration before liver transplantation.肝移植前通过持续动静脉血液滤过纠正严重低钠血症
BMJ. 1988 Dec 10;297(6662):1514-5. doi: 10.1136/bmj.297.6662.1514.
10
Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis.外周动脉血管舒张假说:关于肝硬化时肾钠水潴留起始机制的一种提议
Hepatology. 1988 Sep-Oct;8(5):1151-7. doi: 10.1002/hep.1840080532.

静脉输注白蛋白是治疗肝硬化腹水患者低钠血症的有效方法。

Intravenous albumin infusion is an effective therapy for hyponatraemia in cirrhotic patients with ascites.

作者信息

McCormick P A, Mistry P, Kaye G, Burroughs A K, McIntyre N

机构信息

Academic Department of Medicine, Royal Free Hospital School of Medicine, Hampstead, London.

出版信息

Gut. 1990 Feb;31(2):204-7. doi: 10.1136/gut.31.2.204.

DOI:10.1136/gut.31.2.204
PMID:2311979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1378381/
Abstract

The treatment of moderate to severe hyponatraemia in patients with decompensated liver disease is unsatisfactory. We report our preliminary experience using intravenous infusion of albumin to treat this condition. Three patients with cirrhosis, ascites, and hyponatraemia responded satisfactorily to treatment; one patient with fulminant hepatitis B did not respond. Intravenous albumin infusion is a safe and effective therapy for patients with cirrhosis complicated by hyponatraemia. Its main role may be in preparing patients for surgery, particularly liver transplantation.

摘要

失代偿性肝病患者中重度低钠血症的治疗效果并不理想。我们报告了使用静脉输注白蛋白治疗这种情况的初步经验。三名患有肝硬化、腹水和低钠血症的患者对治疗反应良好;一名爆发性乙型肝炎患者没有反应。静脉输注白蛋白对肝硬化合并低钠血症患者是一种安全有效的治疗方法。其主要作用可能是为患者进行手术,尤其是肝移植做准备。