Ionescu J, Tapu V, Eskenasy A
Morphol Embryol (Bucur). 1979 Oct-Dec;25(4):341-8.
A series of sixty lung tumors operated during 1977 were histoenzymatically investigated (12 macrocellular carcionomas, 4 microcellular, 18 epidermoid, 18 cylindrocubic, 2 bronchiolo-alveolar cell carcinomas, 4 lung fibroblastic sarcomas, and 2 benign lung tumors: a haemangioma and a carcinoid tumor). There were tested 25 enzymes, hydrolases and oxidoreductases of different metabolic pathways. The histoenzymatic analysis of the neoplastic lung tissue compared with the normal adult human lung tissue pointed to a shifting of the metabolic balance, with the decrease of enzyme activities belonging to the Krebs tricarboxylic acid cycle and with the increase or maintenance of the level of enzymic activities belonging to the Embden-Meyerhoff-Parnas pathway and to the pentose shunt. The enzymes intervening in the protidic activity in all the malignant tumors of the lung. Some hydrolases were also more active lung tissue pointed out the existence of close relations between the normal epithelia and the cylindrocubic and bronchiolo-alveolar types, and of distant ones with the epidermoid and microcellular carcinomas which suffered more accentuated ecogenetic influences (stopping of differentiation/maturation, metaplasia) during the complex oncogenetic process.
对1977年手术切除的60例肺肿瘤进行了组织酶学研究（12例大细胞癌、4例小细胞癌、18例鳞状细胞癌、18例圆柱立方细胞癌、2例细支气管肺泡细胞癌、4例肺纤维肉瘤以及2例良性肺肿瘤：1例血管瘤和1例类癌肿瘤）。检测了25种酶，包括不同代谢途径的水解酶和氧化还原酶。将肿瘤肺组织与正常成人肺组织进行组织酶学分析，结果表明代谢平衡发生了改变，属于三羧酸循环的酶活性降低，而属于糖酵解途径和磷酸戊糖途径的酶活性水平升高或维持不变。这些酶参与了肺所有恶性肿瘤中的蛋白质活性过程。一些水解酶在肺组织中也更具活性，这表明正常上皮细胞与圆柱立方细胞癌和细支气管肺泡细胞癌类型之间存在密切关系，而与鳞状细胞癌和小细胞癌的关系较远，后者在复杂的肿瘤发生过程中受到更明显的生态遗传影响（分化/成熟停止、化生）。
