Nigro G, Comi L I, Politano L, Bain R J
Department of Cardiomyology and Myology, Naples University, Italy.
Int J Cardiol. 1990 Mar;26(3):271-7. doi: 10.1016/0167-5273(90)90082-g.
To assess the incidence, nature and evolution of cardiac disease in Duchenne muscular dystrophy, 328 patients were studied between 1976 and 1987 for periods varying from 3 to 11 years. Patients underwent regular clinical examination, electrocardiography, echocardiography and radiological assessment. Pre-clinical cardiac involvement was found in 25% of patients under 6 years old increasing to 59% between the ages of 6 and 10 years and then declining in incidence with age. Clinically apparent cardiomyopathy is first evident after 10 years of age and increases in incidence with age, being present in all patients over 18 years of age. Its clinical impact is discussed.
为评估杜氏肌营养不良症中心脏病的发病率、性质及演变情况，1976年至1987年间对328例患者进行了为期3至11年的研究。患者接受了定期的临床检查、心电图检查、超声心动图检查及放射学评估。6岁以下患者中25%存在临床前期心脏受累，6至10岁时这一比例增至59%，随后发病率随年龄增长而下降。临床上明显的心肌病在10岁后首次显现，且发病率随年龄增长而增加，18岁以上的所有患者均有该病。文中讨论了其临床影响。
