Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Pingtung County, Taiwan, ROC.
Food Chem. 2013 Jan 15;136(2):1086-94. doi: 10.1016/j.foodchem.2012.09.017. Epub 2012 Sep 16.
Natural herbal medications may be one answer to the worldwide epidemic of obesity. This study examines the effects of Cassia seed ethanol extract (CSEE) upon lipid accumulation in white adipose tissue (WAT). CSEE exhibited a significant concentration-dependent decrease in the intracellular accumulation of trigycerides in 3T3-L1 adipocytes. After being fed a high-fat diet (HFD) for 2 weeks, rats were fed CSEE (100, 200 or 300 mg/kg) once daily for 8 weeks. CSEE caused dose-related reductions in body weight gain (as well as plasma lipid levels and epididymal WAT sizes in HFD-fed rats). CSEE enhanced the phosphorylation of AMP-activated protein kinase (AMPK) and its primary downstream targeting enzyme, acetyl-CoA carboxylase, up-regulated gene expression of carnitine palmitoyl transferase 1, and down-regulated sterol regulatory element-binding protein 1 and fatty acid synthase protein levels in epididymal WAT of HFD-fed rats. CSEE could attenuate lipid accumulation in WAT via AMPK signaling pathway activation.
天然草药可能是解决全球肥胖问题的方法之一。本研究探讨了决明子乙醇提取物（CSEE）对白色脂肪组织（WAT）中脂质积累的影响。CSEE 可显著浓度依赖性地减少 3T3-L1 脂肪细胞内甘油三酯的蓄积。经过 2 周的高脂肪饮食（HFD）喂养后，大鼠每天给予 CSEE（100、200 或 300mg/kg）治疗 8 周。CSEE 可降低体重增加（以及 HFD 喂养大鼠的血浆脂质水平和附睾 WAT 大小）。CSEE 增强了 AMP 激活的蛋白激酶（AMPK）及其主要下游靶酶乙酰辅酶 A 羧化酶的磷酸化，上调了附睾 WAT 中肉碱棕榈酰转移酶 1 的基因表达，并下调了固醇调节元件结合蛋白 1 和脂肪酸合酶蛋白水平。CSEE 通过激活 AMPK 信号通路来减轻 WAT 中的脂质积累。
