眼球快速运动峰值速度与血清苯二氮䓬浓度之间的关系。
The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.
作者信息
Bittencourt P R, Wade P, Smith A T, Richens A
出版信息
Br J Clin Pharmacol. 1981 Oct;12(4):523-33. doi: 10.1111/j.1365-2125.1981.tb01261.x.
Abstract
1 Six healthy male volunteers received single oral doses of 10 mg diazepam, 20 mg temazepam, 15 mg flurazepam, 5 mg nitrazepam, 10 mg desmethyl-diazepam and placebo in a double-blind randomized fashion. 2 Peak velocity of saccadic eye movements, serum benzodiazepine concentration, and subjective ratings of wakefulness and co-ordination were measured at intervals up to 12 h after drug administration. 3 All active treatments produced a statistically significant decrease in peak saccadic velocity. The effect of temazepam and diazepam was generally more pronounced than that of flurazepam, nitrazepam and desmethyl-diazepam. 4 There were log-linear correlations between peak saccadic velocity and serum benzodiazepine concentration after ingestion of temazepam, diazepam and nitrazepam. 5 These results demonstrate a clear relationship between serum benzodiazepine concentration and its effect on a convenient measure of brainstem reticular formation function.
摘要
- 六名健康男性志愿者以双盲随机方式接受了单次口服剂量的10毫克地西泮、20毫克替马西泮、15毫克氟西泮、5毫克硝西泮、10毫克去甲基地西泮和安慰剂。2. 在给药后长达12小时的间隔时间内，测量了眼球快速运动的峰值速度、血清苯二氮䓬浓度以及清醒和协调能力的主观评分。3. 所有活性治疗均使眼球快速运动峰值速度出现统计学上的显著下降。替马西泮和地西泮的效果通常比氟西泮、硝西泮和去甲基地西泮更明显。4. 摄入替马西泮、地西泮和硝西泮后，眼球快速运动峰值速度与血清苯二氮䓬浓度之间存在对数线性相关性。5. 这些结果表明血清苯二氮䓬浓度与其对脑干网状结构功能的便捷测量指标的影响之间存在明确关系。
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