Yoshida Tokuyuki, Yoshioka Yasuo, Tsutsumi Yasuo
Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Yakugaku Zasshi. 2012;132(11):1231-6. doi: 10.1248/yakushi.12-00232-4.
A diverse array of nanomaterials (NMs), such as amorphous nanosilica (nSP), carbon nanotubes and titanium dioxide, has become widespread in use due to the development of nanotechnology. NMs are already being applied in universal fields because they have unique physicochemical properties. On the other hands, the safety of NMs has not been well assessed, because NMs have been considered as safe as common larger sized materials which are known not to be absorbed by the body. Because NMs have the potential to improve the quality of human life, it is essential to ensure the safety of NMs and provide information for designing safer NMs. In this regard, we studied the biological distribution and hazard identification of nSP following dermal administration, because nSP is used NMs in the cosmetics field. In the future, our study would help to set the no observed adverse effect level (NOAEL) and acceptable daily intake (ADI), and be useful information for the safety/hazard assessment and evaluation.
由于纳米技术的发展，各种各样的纳米材料（NMs），如无定形纳米二氧化硅（nSP）、碳纳米管和二氧化钛，已得到广泛应用。纳米材料因其独特的物理化学性质已被应用于多个领域。另一方面，纳米材料的安全性尚未得到充分评估，因为纳米材料一直被认为与已知不会被人体吸收的普通较大尺寸材料一样安全。由于纳米材料有改善人类生活质量的潜力，确保纳米材料的安全性并提供设计更安全纳米材料的信息至关重要。在这方面，我们研究了经皮给药后nSP的生物分布和危害识别，因为nSP是化妆品领域中使用的纳米材料。未来，我们的研究将有助于确定无观察到不良作用水平（NOAEL）和每日允许摄入量（ADI），并为安全/危害评估和评价提供有用信息。
