Department of Neurology, General Hospital of Shen-Yang Military Region, Shen Yang 110840, PR China.
Neurosci Lett. 2012 Dec 7;531(2):145-8. doi: 10.1016/j.neulet.2012.10.040. Epub 2012 Nov 2.
Recently, P2X7 receptor (P2X7R) has been found to contribute to the development of inflammatory pain, however, the role of spinal P2X7R is not clear. The present study was designed to determine the roles of spinal P2X7R in the bee venom (BV) model, characterized by multiple pain-related behaviors and obvious inflammatory edema. We determined the effects of P2X7R antagonist A438790 on BV-induced PSN, mechanical allodynia and inflammatory swelling. Pre-treatment with intrathecal administration of A438079 significantly inhibited BV-induced PSN and mechanical allodynia in a dose-dependent manner, but had no effect on BV-induced inflammatory swelling. These data suggest that the activation of spinal P2X7Rs may play a key role in BV-induced nociception, but not inflammation.
最近，P2X7 受体（P2X7R）被发现有助于炎症性疼痛的发展，然而，脊髓 P2X7R 的作用尚不清楚。本研究旨在确定脊髓 P2X7R 在蜂毒（BV）模型中的作用，该模型具有多种与疼痛相关的行为和明显的炎症性水肿。我们确定了 P2X7R 拮抗剂 A438790 对 BV 诱导的 PSN、机械性痛觉过敏和炎症性肿胀的影响。鞘内给予 A438079 预处理可显著剂量依赖性抑制 BV 诱导的 PSN 和机械性痛觉过敏，但对 BV 诱导的炎症性肿胀无影响。这些数据表明，脊髓 P2X7R 的激活可能在 BV 诱导的痛觉过敏中起关键作用，但在炎症中不起作用。
