Crowther J A, Miller J M, Kileny P R
Department of Otolaryngology, Glasgow Royal Infirmary, U.K.
Hear Res. 1990 Jan;43(2-3):115-20. doi: 10.1016/0378-5955(90)90220-j.
Increased recent interest in the middle latency response (MLR) has necessitated a clarification of the possible effects of anesthesia on the response. Our study was designed to examine the changes, in the guinea pig MLR, which occurred during anesthesia with ketamine, xylazine or both ketamine and xylazine. Under anesthesia the response remained present and the threshold remained stable. After anesthesia, significant changes in amplitude, latency, and general morphology of the waveform took place, however these were consistent and predictable. For studies requiring the MLR, it is best to avoid anesthetic agents. However, with care the MLR can be used as a reliable measure of auditory system sensitivity under anesthesia.
近期对中潜伏期反应（MLR）的兴趣增加，因此有必要阐明麻醉对该反应可能产生的影响。我们的研究旨在检查豚鼠MLR在氯胺酮、赛拉嗪或氯胺酮与赛拉嗪联合麻醉期间发生的变化。在麻醉状态下，反应仍然存在，阈值保持稳定。然而，麻醉后，波形的幅度、潜伏期和总体形态发生了显著变化，但这些变化是一致且可预测的。对于需要MLR的研究，最好避免使用麻醉剂。然而，谨慎操作的话，MLR可作为麻醉状态下听觉系统敏感性的可靠测量指标。
