Burton M J, Miller J M, Kileny P R
Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor.
Arch Otolaryngol Head Neck Surg. 1989 Jan;115(1):59-62. doi: 10.1001/archotol.1989.01860250061027.
The electrically evoked auditory brain-stem response has been used in the past to assess auditory system function with regard to cochlear prosthesis application. The brief latency of the response makes it susceptible to electrical artifact contamination, and waveform identification is often difficult. As a possible alternative for a noninvasive measure of system excitability, the middle-latency response (MLR), elicited by electrical stimulation, was investigated. Middle-latency responses were recorded in response to acoustic and round-window electrical stimulation in albino guinea pigs. Acoustic and electrically evoked MLR waveforms were similar, as were their respective latency/intensity functions. Amplitude/intensity functions for the electric MLR showed greater variability than acoustically evoked MLR functions. The electric MLR is readily evoked and relatively insensitive to electrical artifact in the guinea pig. It is potentially a useful tool in assessing the integrity of auditory pathways and consequently in the development of diagnostic tests for cochlear implant candidates.
过去，电诱发听觉脑干反应已被用于评估与人工耳蜗应用相关的听觉系统功能。该反应的潜伏期较短，使其容易受到电伪迹污染，并且波形识别通常很困难。作为一种用于系统兴奋性非侵入性测量的可能替代方法，研究了由电刺激诱发的中潜伏期反应（MLR）。在白化豚鼠中记录了对声音和圆窗电刺激的中潜伏期反应。声音诱发和电诱发的MLR波形相似，它们各自的潜伏期/强度函数也相似。电MLR的振幅/强度函数比声音诱发的MLR函数表现出更大的变异性。在豚鼠中，电MLR很容易诱发且对电伪迹相对不敏感。它可能是评估听觉通路完整性的有用工具，因此可用于开发针对人工耳蜗候选者的诊断测试。
