Frankfurt School of Finance and Management, Sonnemannstr. 9-11, 60314, Frankfurt am Main, Germany,
Eur J Health Econ. 2013 Dec;14(6):901-9. doi: 10.1007/s10198-012-0434-3. Epub 2012 Nov 3.
In cost-effectiveness analyses, models are used typically to synthesize the best available data and/or extrapolate beyond clinical trial data. Ideally, models should be validated both internally and externally. The purpose of this paper is to suggest a test for internal validation of models where several interventions for the same clinical indication are compared. To the best of our knowledge, such a specific test does not yet exist. There are four versions of the test, which consider the relationship between incremental downstream costs and effects in the case of a single or several endpoints. We apply two versions of the validation test to published cost-effectiveness analyses of physical activity programs and demonstrate internal validity of the model in one study and lack of internal validity of the model in the other study.
在成本效益分析中，模型通常用于综合最佳现有数据和/或推断临床试验数据之外的信息。理想情况下，模型应进行内部和外部验证。本文的目的是提出一种针对模型内部验证的测试方法，该方法可用于比较针对同一临床适应证的多种干预措施。据我们所知，目前还没有专门针对这种情况的测试方法。该测试有四个版本，考虑了在单个或多个终点情况下增量下游成本和效果之间的关系。我们将验证测试的两个版本应用于已发表的体力活动计划成本效益分析，并证明了其中一项研究中的模型具有内部有效性，而另一项研究中的模型则缺乏内部有效性。
