一种新型小分子可促进人类体细胞重编程为多能状态，并支持人类多能干细胞的未分化状态维持。
A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells.
机构信息
Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, S. Korea.
出版信息
Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12509-13. doi: 10.1002/anie.201206691. Epub 2012 Nov 4.
PMID:23125037
Abstract
Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
摘要
多潜能性增强剂
RSC133，一种吲哚丙烯酸/吲哚丙酸的新型合成衍生物，通过抑制组蛋白去乙酰化酶和 DNA 甲基转移酶表现出双重活性。此外，它能有效地促进人类体细胞重编程为多能状态，并有助于人类多能干细胞（hPSC）的生长和维持。
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