聚（酰胺胺）（PAMAM）树枝状大分子作为抗菌剂的表面改性
Surface Modification of Poly(amidoamine) (PAMAM) Dendrimer as Antimicrobial Agents.
作者信息
Charles Shakira, Vasanthan Nadarajah, Kwon Dong, Sekosan Gabriela, Ghosh Subhas
机构信息
Department of Chemistry, Long Island University, Brooklyn, NY 11201.
出版信息
Tetrahedron Lett. 2012 Dec 5;53(49):6670-6675. doi: 10.1016/j.tetlet.2012.09.098. Epub 2012 Sep 28.
Abstract
Poly(amidoamine) (PAMAM) (G3) dendrimer was modified into quaternary ammonium salts using tertiary amines with different chain lengths: dimethyldodecyl amine, dimethylhexyl amine, and dimethylbutyl amine using an efficient synthetic route. The antimicrobial activity of these dendrimer ammonium salts against Staphylococcus and E-coli bacteria was examined using the disc diffusion method. It was found that quaternary ammonium salt prepared with the dimethyldodecyl amine exhibits antimicrobial efficacy against Staphalococus and E.coli bacteria.
摘要
使用高效合成路线，通过具有不同链长的叔胺：二甲基十二烷基胺、二甲基己基胺和二甲基丁基胺，将聚（酰胺胺）（PAMAM）（G3）树枝状大分子改性为季铵盐。采用纸片扩散法检测了这些树枝状大分子铵盐对金黄色葡萄球菌和大肠杆菌的抗菌活性。结果发现，用二甲基十二烷基胺制备的季铵盐对金黄色葡萄球菌和大肠杆菌具有抗菌效果。
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