Bae Jungin, Son Woo-Sung, Yoo Kyung-Hyeon, Yoon Seog-Young, Bae Moon-Kyoung, Lee Dong Joon, Ko Ching-Chang, Choi Youn-Kyung, Kim Yong-Il
Department of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan 50612, Korea.
School of Materials Science and Engineering, Pusan National University, Busan 46241, Korea.
Nanomaterials (Basel). 2019 Apr 10;9(4):591. doi: 10.3390/nano9040591.
Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) (PAMAM@MBN) on DH treatment, examining the ion-releasing effect, dentin remineralization, and the occluding effect of dentinal tubules. We synthesized MBN and PAMAM@MBN. After soaking each sample in simulated body fluid (SBF), we observed ion-releasing effects and dentin remineralization effects for 30 days. Also, we prepared 30 premolars to find the ratio of occluded dentinal tubules after applying MBN and PAMAM@MBN, respectively. The results showed that PAMAM did not disrupt the calcium ion-releasing ability or the dentin remineralization of MBN. The PAMAM@MBN showed a better occluding effect for dentinal tubules than that of MBN ( < 0.05). In terms of dentinal tubule occlusion, the gap between MBN was well occluded due to PAMAM. This implies that PAMAM@MBN could be effectively used in dentinal tubule sealing and remineralization.
牙本质过敏症（DH）是最常见的临床病症之一，通常与牙本质表面暴露有关。在本研究中，我们确定了聚（酰胺胺）（PAMAM）树枝状大分子包覆的介孔生物活性玻璃纳米颗粒（MBN）（PAMAM@MBN）对DH治疗的有效性，研究了离子释放效应、牙本质再矿化以及牙本质小管的封闭作用。我们合成了MBN和PAMAM@MBN。将每个样品浸泡在模拟体液（SBF）中后，我们观察了30天的离子释放效应和牙本质再矿化效应。此外，我们制备了30颗前磨牙，分别应用MBN和PAMAM@MBN后，观察牙本质小管的封闭率。结果表明，PAMAM不会破坏MBN的钙离子释放能力或牙本质再矿化能力。PAMAM@MBN对牙本质小管的封闭效果优于MBN（<0.05）。在牙本质小管封闭方面，由于PAMAM的作用，MBN之间的间隙被很好地封闭。这意味着PAMAM@MBN可有效地用于牙本质小管封闭和再矿化。
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