晚期髓样和分化型甲状腺癌的联合化疗。II期研究。
Combination chemotherapy of advanced medullary and differentiated thyroid cancer. Phase II study.
作者信息
Scherübl H, Raue F, Ziegler R
机构信息
Department of Internal Medicine I, University of Heidelberg, Federal Republic of Germany.
出版信息
J Cancer Res Clin Oncol. 1990;116(1):21-3. doi: 10.1007/BF01612635.
Abstract
A group of 20 patients with advanced medullary (MTC) or differentiated thyroid carcinoma (DTC) received a combination chemotherapy of doxorubicin (50 mg/m2), cisplatin (60 mg/m2) and vindesine (3 mg/m2). In the 18 (10 MTC, 8 DTC) evaluable patients only 1 partial remission (in a patient with MTC) and 3 minor responses (in 3 patients with DTC) were observed. These responses lasted for 15, 9, 13, and 22 months, respectively. Three MTC patients suffered from progressive disease and "no change" was seen in the other 11 patients. Toxicity, including 1 severe case of cardiomyopathy, was considerable. Thus, the combination chemotherapy of doxorubicin, cisplatin and vindesine has failed to prove superior to the commonly applied doxorubicin monotherapy in patients with advanced medullary or differentiated thyroid carcinoma.
摘要
一组20例晚期髓样甲状腺癌（MTC）或分化型甲状腺癌（DTC）患者接受了阿霉素（50mg/m²）、顺铂（60mg/m²）和长春地辛（3mg/m²）的联合化疗。在18例（10例MTC，8例DTC）可评估患者中，仅观察到1例部分缓解（1例MTC患者）和3例轻度缓解（3例DTC患者）。这些缓解分别持续了15、9、13和22个月。3例MTC患者病情进展，其他11例患者病情“无变化”。毒性反应相当严重，包括1例严重的心肌病。因此，对于晚期髓样或分化型甲状腺癌患者，阿霉素、顺铂和长春地辛的联合化疗并未证明优于常用的阿霉素单一疗法。
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