依维莫司治疗转移性肾细胞癌：长庚纪念医院的初步经验。
Everolimus in metastatic renal cell carcinoma: preliminary experience from Chang Gung Memorial Hospital.
作者信息
Huang Wen-Kuan, Liaw Chuang-Chi, Pang See-Tong, Chuang Cheng-Keng, Chiang Yang-Jen, Wu Chun-Te, Chang Ying-Hsu, Wang Hung-Ming, Lin Yung-Chang, Hsieh Jia-Juan, Ou Li-Ying, Tsai Shih-I, Yang Chih-Hsun, Yang Cheng-Ta, Chang John Wen-Cheng
机构信息
Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.
出版信息
Chang Gung Med J. 2012 Sep-Oct;35(5):402-7. doi: 10.4103/2319-4170.105478.
BACKGROUND
Everolimus has been approved for second-line treatment of patients with metastatic renal cell carcinoma (mRCC) after failure of sorafenib or sunitinib. The purpose of this retrospective study was to assess the efficacy and safety of everolimus in Taiwanese patients with mRCC.
METHODS
Between March 2009 and August 2011, 24 mRCC patients treated with everolimus were analyzed. Prior to everolimus, each patient had received therapy with at least one vascular endothelial growth factor receptor-tyrosine kinase inhibitor. Progression-free survival (PFS) and overall survival (OS) were estimated according to the Kaplan-Meier method.
RESULTS
Fifteen patients (62.5%) achieved stable disease. The median PFS was 7.1 months (95% confidence interval, 3.6-10.5 months). The median OS was 20.7 months (95% confidence interval, 5.0-36.4 months). The most frequent non-hematologic adverse events with everolimus were mucositis, rash, epistaxis and pneumonitis.
CONCLUSIONS
Everolimus is an effective second-line treatment for Taiwanese patients with mRCC. The toxicity is tolerable and manageable.
背景
依维莫司已被批准用于索拉非尼或舒尼替尼治疗失败后的转移性肾细胞癌（mRCC）患者的二线治疗。这项回顾性研究的目的是评估依维莫司在台湾mRCC患者中的疗效和安全性。
方法
对2009年3月至2011年8月期间接受依维莫司治疗的24例mRCC患者进行分析。在使用依维莫司之前，每位患者至少接受过一种血管内皮生长因子受体酪氨酸激酶抑制剂的治疗。根据Kaplan-Meier方法估计无进展生存期（PFS）和总生存期（OS）。
结果
15例患者（62.5%）病情稳定。中位PFS为7.1个月（95%置信区间，3.6 - 10.5个月）。中位OS为20.7个月（95%置信区间，5.0 - 36.4个月）。依维莫司最常见的非血液学不良事件为粘膜炎、皮疹、鼻出血和肺炎。
结论
依维莫司是台湾mRCC患者有效的二线治疗药物。其毒性是可耐受和可管理的。
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