Kamper-Jørgensen Mads
Department of Public Health, Section of Social Medicine, University of Copenhagen, Copenhagen, Denmark.
Chimerism. 2012 Jul-Dec;3(3):72-3. doi: 10.4161/chim.22770. Epub 2012 Jul 1.
Recently, we reported microchimerism to be oppositely associated with maternal breast and colon cancer. In women with a blood test positive for male microchimerism the risk of breast cancer development was reduced to one third, whereas the risk of colon cancer was elevated 4-fold. In this article addendum, I report the survival of cases in the original study after being diagnosed with cancer. Despite small numbers, the analysis suggests that microchimerism may be positively associated with survival after breast and maybe colon cancer diagnosis. Despite the findings on colon cancer in our original report, I speculate whether microchimerism could have a general beneficial role in cancer, which in some sites may not be evident because an allogeneic maternal immune reaction hastens cancer development.
最近，我们报告了微嵌合体与母亲患乳腺癌和结肠癌呈相反关联。在血液检测显示男性微嵌合体呈阳性的女性中，患乳腺癌的风险降至三分之一，而患结肠癌的风险则升高了4倍。在本文附录中，我报告了原始研究中确诊患癌病例的生存情况。尽管病例数量较少，但分析表明，微嵌合体可能与乳腺癌以及或许结肠癌诊断后的生存呈正相关。尽管我们在原始报告中有关于结肠癌的研究结果，但我推测微嵌合体在癌症中是否可能具有普遍的有益作用，而在某些部位这种作用可能不明显，因为同种异体的母体免疫反应会加速癌症发展。
