Canatan Duran
Akdeniz Kan Hastaliklari Vakfi, Antelsan Is Merkezi, Kisla Mh Gulluk Cd., Antalya, Turkey.
J Pediatr Hematol Oncol. 2013 Jan;35(1):24-7. doi: 10.1097/MPH.0b013e3182755f1e.
The Thalassemia center of Antalya State Hospital was established in 1994 in Antalya, Turkey. The number of newborns with thalassemia decreased statistically because of actions taken as a result of prevention studies. A total of 388 patients, including 246 with thalassemia major (63.4%), 86 with thalassemia intermediate (22.1%), 23 with sickle cell+β-thalassemia (5.9%), 20 with sickle cell disease (5.1%), and 13 with other hemoglobin abnormalities (3.3%), were studied. Complications were found to be as follows: cardiomyopathy in 45 of them (11.5%), diabetes mellitus in 10 (2.5%), hypothyroidism in 17 (4.3%), hypoparathyroidism in 2 (0.5%), osteoporosis in 53 (13.6%), growth retardation in 110 (28.3%), and hypogonadism in 75 patients (19.3%). The incidence of autoantibody and alloantibody in patients with thalassemia major was 5.6% and 10.5%, respectively. Transfusion-transmission diseases evaluated in patients found the incidence of hepatit A virus IgG to be 97.5%, that of HBs Ab to be 99.5%, HBs Ag to be 0.5%, HCV Ab to be 18%, CMV IgG to be 72.3%, CMV IgM to be 2%, and HIV-Ab to be 0%. Therefore, for the first time in our country the thalassemia center was established as a model and included subunits and a team. It served all patients for 15 years until the team was dispersed; thereafter, most of the patients were not followed up on a regular basis.
安塔利亚州立医院地中海贫血中心于1994年在土耳其安塔利亚成立。由于预防研究采取的措施，地中海贫血新生儿数量在统计学上有所下降。共研究了388例患者，其中重型地中海贫血246例（63.4%），中间型地中海贫血86例（22.1%），镰状细胞+β地中海贫血23例（5.9%），镰状细胞病20例（5.1%），其他血红蛋白异常13例（3.3%）。发现的并发症如下：其中45例（11.5%）患有心肌病，10例（2.5%）患有糖尿病，17例（4.3%）患有甲状腺功能减退症，2例（0.5%）患有甲状旁腺功能减退症，53例（13.6%）患有骨质疏松症，110例（28.3%）生长发育迟缓，75例（19.3%）患有性腺功能减退症。重型地中海贫血患者自身抗体和同种抗体的发生率分别为5.6%和10.5%。对患者评估的输血传播疾病发现，甲型肝炎病毒IgG的发生率为97.5%，乙肝抗体为99.5%，乙肝表面抗原为0.5%，丙肝抗体为18%，巨细胞病毒IgG为72.3%，巨细胞病毒IgM为2%，艾滋病毒抗体为0%。因此，我国首次将地中海贫血中心作为一个模式建立起来，包括多个亚单位和一个团队。该中心为所有患者服务了15年，直到团队解散；此后，大多数患者没有得到定期随访。
