• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肺炎克雷伯菌中碳青霉烯类耐药的流行病学和耐药机制：一项多中心研究。

Epidemiology and resistance mechanisms to imipenem in Klebsiella pneumoniae: a multicenter study.

机构信息

Department of Clinical Laboratory, Central Hospital of Taizhou City, Taizhou, Zhejiang, PR China.

出版信息

Mol Med Rep. 2013 Jan;7(1):21-5. doi: 10.3892/mmr.2012.1155. Epub 2012 Oct 25.

DOI:10.3892/mmr.2012.1155
PMID:23128404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3572730/
Abstract

Four clinical isolates of imipenem-resistant Klebsiella pneumoniae were isolated from clinical patient specimens and from samples obtained from hygienic surveillance in our hospital. We examined their minimum inhibitory concentration (MIC) to various types of antibiotics, detected the carbapenemases by a modified Hodge test and analyzed the genotype and homogeneity. The enzyme, Klebsiella pneumoniae carbapenemase (KPC)-2, was detected in all four isolates and this was the main cause of their imipenem resistance. In addition, these four isolates also contained the extended-spectrum β-lactamase (ESBL) gene blaCTX-M-9 and the cephalosporinase (AmpC) gene blaDHA-1, which resulted in multidrug resistance.

摘要

从临床患者标本和我院卫生监测样本中分离出 4 株耐亚胺培南肺炎克雷伯菌临床分离株。我们检测了它们对各种类型抗生素的最小抑菌浓度（MIC），通过改良 Hodge 试验检测碳青霉烯酶，并分析了基因型和同源性。所有 4 株分离株均检测到酶，肺炎克雷伯菌碳青霉烯酶（KPC）-2，这是它们对亚胺培南耐药的主要原因。此外，这 4 株分离株还含有超广谱β-内酰胺酶（ESBL）基因 blaCTX-M-9 和头孢菌素酶（AmpC）基因 blaDHA-1，导致多重耐药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd7/3572730/874573d7cae3/MMR-07-01-0021-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd7/3572730/8df90e2cfefc/MMR-07-01-0021-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd7/3572730/e43609869cbb/MMR-07-01-0021-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd7/3572730/874573d7cae3/MMR-07-01-0021-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd7/3572730/8df90e2cfefc/MMR-07-01-0021-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd7/3572730/e43609869cbb/MMR-07-01-0021-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd7/3572730/874573d7cae3/MMR-07-01-0021-g04.jpg

相似文献

1
Epidemiology and resistance mechanisms to imipenem in Klebsiella pneumoniae: a multicenter study.肺炎克雷伯菌中碳青霉烯类耐药的流行病学和耐药机制：一项多中心研究。
Mol Med Rep. 2013 Jan;7(1):21-5. doi: 10.3892/mmr.2012.1155. Epub 2012 Oct 25.
2
The Role of OmpK35, OmpK36 Porins, and Production of β-Lactamases on Imipenem Susceptibility in Klebsiella pneumoniae Clinical Isolates, Cairo, Egypt.埃及开罗肺炎克雷伯菌临床分离株中OmpK35、OmpK36孔蛋白及β-内酰胺酶产生对亚胺培南敏感性的作用
Microb Drug Resist. 2015 Dec;21(6):577-80. doi: 10.1089/mdr.2014.0226. Epub 2015 May 6.
3
Phenotypic and genotypic screening and clonal analysis of carbapenem-resistant Klebsiella pneumoniae at a single hospital.单家医院碳青霉烯类耐药肺炎克雷伯菌的表型和基因型筛查及克隆分析。
Microb Drug Resist. 2011 Jun;17(2):251-7. doi: 10.1089/mdr.2010.0116. Epub 2011 Feb 19.
4
Prevalence of a New Variant OXA-204 and OXA-48 Carbapenemases Plasmids Encoded in Klebsiella pneumoniae Clinical Isolates in Tunisia.突尼斯肺炎克雷伯菌临床分离株中编码新型OXA-204和OXA-48碳青霉烯酶质粒的流行情况。
Microb Drug Resist. 2018 Mar;24(2):142-149. doi: 10.1089/mdr.2016.0236. Epub 2017 Jul 24.
5
Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11.5 年间加拿大医院分离的产超广谱β-内酰胺酶、AmpC 酶和碳青霉烯酶大肠埃希菌和肺炎克雷伯菌的分子流行病学研究：CANWARD 2007-11。
J Antimicrob Chemother. 2013 May;68 Suppl 1:i57-65. doi: 10.1093/jac/dkt027.
6
KPC-Producing Klebsiella pneumoniae Isolates in Croatia: A Nationwide Survey.克罗地亚产KPC的肺炎克雷伯菌分离株：一项全国性调查。
Microb Drug Resist. 2016 Dec;22(8):662-667. doi: 10.1089/mdr.2015.0150. Epub 2015 Dec 28.
7
Prevalence and characteristics of ertapenem-resistant Klebsiella pneumoniae isolates in a Taiwanese university hospital.台湾一家大学医院耐厄他培南的肺炎克雷伯菌分离株的流行情况和特征。
Microb Drug Resist. 2011 Jun;17(2):259-66. doi: 10.1089/mdr.2010.0115. Epub 2011 Feb 25.
8
The mechanism of high-level carbapenem resistance in Klebsiella pneumoniae: underlying Ompk36-deficient strains represent a threat of emerging high-level carbapenem-resistant K. pneumoniae with IMP-1 β-lactamase production in Japan.高产碳青霉烯类耐药肺炎克雷伯菌的机制：产 IMP-1 型β-内酰胺酶的 OmpK36 缺陷株代表了日本高产碳青霉烯类耐药肺炎克雷伯菌的新威胁。
Microb Drug Resist. 2013 Aug;19(4):274-81. doi: 10.1089/mdr.2012.0248. Epub 2013 Mar 20.
9
[Investigation of the susceptibilities of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. strains to ertapenem and other carbapenems].产超广谱β-内酰胺酶大肠埃希菌和克雷伯菌属菌株对厄他培南及其他碳青霉烯类药物的敏感性研究
Mikrobiyol Bul. 2011 Jan;45(1):28-35.
10
In vivo selection of imipenem-resistant Klebsiella pneumoniae producing extended-spectrum beta-lactamase CTX-M-15 and plasmid-encoded DHA-1 cephalosporinase.产超广谱β-内酰胺酶 CTX-M-15 和质粒介导的 DHA-1 头孢菌素酶的耐碳青霉烯类肺炎克雷伯菌的体内选择。
Int J Antimicrob Agents. 2010 Mar;35(3):265-8. doi: 10.1016/j.ijantimicag.2009.10.021.

引用本文的文献

1
Epidemiology and resistance features of Acinetobacter baumannii isolates from the ward environment and patients in the burn ICU of a Chinese hospital.中国一家医院烧伤重症监护病房病房环境及患者中分离的鲍曼不动杆菌的流行病学和耐药特征
J Microbiol. 2016 Aug;54(8):551-8. doi: 10.1007/s12275-016-6146-0. Epub 2016 Aug 2.
2
Molecular characterization of multidrug-resistant Klebsiella pneumoniae isolates.耐多药肺炎克雷伯菌分离株的分子特征分析
Braz J Microbiol. 2015 Jul 1;46(3):759-68. doi: 10.1590/S1517-838246320140138. eCollection 2015 Jul-Sep.

本文引用的文献

1
Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 β-lactamase.产 KPC-2 型β-内酰胺酶的大肠杆菌序列型 410（ST410）的出现。
Int J Antimicrob Agents. 2012 Mar;39(3):247-50. doi: 10.1016/j.ijantimicag.2011.11.003. Epub 2012 Jan 9.
2
Emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in South Africa.南非出现新德里金属β-内酰胺酶（NDM-1）和肺炎克雷伯菌碳青霉烯酶（KPC-2）。
J Clin Microbiol. 2012 Feb;50(2):525-7. doi: 10.1128/JCM.05956-11. Epub 2011 Nov 23.
3
[Dissemination of the KPC carbapenemase producing Klebsiella pneumoniae in a hospital in Warsaw, Poland].
[波兰华沙一家医院产KPC碳青霉烯酶肺炎克雷伯菌的传播情况]
Med Dosw Mikrobiol. 2010;62(1):9-20.
4
The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.产肺炎克雷伯菌碳青霉烯酶细菌的真正威胁。
Lancet Infect Dis. 2009 Apr;9(4):228-36. doi: 10.1016/S1473-3099(09)70054-4.
5
Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA.在美国东部不同机构检测到的携带blaKPC的肺炎克雷伯菌分离株的特征分析。
J Antimicrob Chemother. 2009 Mar;63(3):427-37. doi: 10.1093/jac/dkn547. Epub 2009 Jan 20.
6
Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China.中国一株肺炎克雷伯菌分离株中质粒介导的KPC-2
Antimicrob Agents Chemother. 2007 Feb;51(2):763-5. doi: 10.1128/AAC.01053-06. Epub 2006 Dec 4.
7
Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates.肺炎克雷伯菌分离株中质粒介导的碳青霉烯水解β-内酰胺酶KPC-2
J Antimicrob Chemother. 2003 Mar;51(3):711-4. doi: 10.1093/jac/dkg124.
8
Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.从一株耐碳青霉烯类的肺炎克雷伯菌中分离出的新型碳青霉烯水解β-内酰胺酶KPC-1
Antimicrob Agents Chemother. 2001 Apr;45(4):1151-61. doi: 10.1128/AAC.45.4.1151-1161.2001.
9
Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing.解读脉冲场凝胶电泳产生的染色体DNA限制性图谱：细菌菌株分型标准
J Clin Microbiol. 1995 Sep;33(9):2233-9. doi: 10.1128/jcm.33.9.2233-2239.1995.