Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin.
作者信息
Li Wenjing, Zhong Chen, Li Lei, Sun Bingfa, Wang Weiyi, Xu Shutong, Zhang Tianlong, Wang Chunguang, Bao Lan, Ding Jianping
出版信息
Cell Res. 2012 Dec;22(12):1707-11. doi: 10.1038/cr.2012.154. Epub 2012 Nov 6.
Abstract
摘要
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J Neurosci. 2012 Sep 12;32(37):12673-83. doi: 10.1523/JNEUROSCI.0016-12.2012.
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Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization.MEC-17 微管蛋白乙酰转移酶的遗传分离功能影响微管组织。
Curr Biol. 2012 Jun 19;22(12):1057-65. doi: 10.1016/j.cub.2012.03.066. Epub 2012 May 31.
3
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.主要的微管蛋白 K40 乙酰转移酶 alphaTAT1 促进了快速纤毛发生和有效的机械感觉。
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21517-22. doi: 10.1073/pnas.1013728107. Epub 2010 Nov 10.
4
MEC-17 is an alpha-tubulin acetyltransferase.MEC-17 是一种微管相关蛋白乙酰转移酶。
Nature. 2010 Sep 9;467(7312):218-22. doi: 10.1038/nature09324.
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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.组蛋白去乙酰化酶6抑制通过增加微管蛋白乙酰化来弥补亨廷顿舞蹈病中的运输缺陷。
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