如何终止：基因3'端RNA聚合酶II占据、mRNA 3'加工与终止之间的神秘联系
How to stop: the mysterious links among RNA polymerase II occupancy 3' of genes, mRNA 3' processing and termination.
作者信息
Anamika Krishanpal, Gyenis Àkos, Tora Laszlo
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS UMR 7104, INSERM U 964, Université de Strasbourg, Illkirch Cedex, France.
出版信息
Transcription. 2013 Jan-Feb;4(1):7-12. doi: 10.4161/trns.22300. Epub 2012 Nov 6.
Abstract
Eukaryotic genes are transcribed by RNA polymerase II (RNAP II) through cycles of initiation, elongation and termination. Termination remains the least understood stage of transcription. Here we discuss the role of RNAP II occupancy downstream of the 3'ends of genes and its links with termination and mRNA 3' processing.
摘要
真核基因由RNA聚合酶II（RNAP II）通过起始、延伸和终止循环进行转录。终止仍然是转录过程中了解最少的阶段。在这里，我们讨论基因3'端下游RNAP II占据的作用及其与终止和mRNA 3'加工的联系。
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