将信使核糖核酸加工与转录整合

Integrating mRNA processing with transcription.

作者信息

Proudfoot Nick J, Furger Andre, Dye Michael J

机构信息

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.

出版信息

Cell. 2002 Feb 22;108(4):501-12. doi: 10.1016/s0092-8674(02)00617-7.

DOI:10.1016/s0092-8674(02)00617-7

PMID:11909521

Abstract

The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.

摘要

信使核糖核酸（mRNA）的加帽、剪接和聚腺苷酸化加工反应在转录过程中同时发生。它们不仅相互影响彼此的效率和特异性，还受到转录的协调。在整个转录延伸和终止过程中，RNA聚合酶II的磷酸化羧基末端结构域（CTD）与这些mRNA加工反应提供关键的分子接触。