Cell and Developmental Biology Programme, Institute for Research in Biomedicine, Baldiri i Reixac 10, 08028 Barcelona, Spain.
Nat Cell Biol. 2012 Nov;14(11):1126-8. doi: 10.1038/ncb2617.
The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports have now revealed remarkable domain organization within the PCM.
中心体的微管组织成分——中心粒周围物质(PCM),包含多种蛋白质,通常被描述为围绕着中心粒的无定形云。然而,PCM 作为一种无定形基质的日子已经屈指可数了。利用超高分辨率显微镜,有几项研究报告揭示了 PCM 内的显著结构组织。