Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center.
J Atheroscler Thromb. 2013;20(2):178-85. doi: 10.5551/jat.14753. Epub 2012 Nov 7.
The cardio-ankle vascular index (CAVI) reflects overall arterial stiffness from the aorta to the ankle, independent of blood pressure. Cerebral small vessel diseases (SVDs), including white matter lesions (WML), silent lacunar infarction (SLI) and cerebral microbleeds (CMB), are considered to increase the risk of stroke and cognitive impairment further. We aimed to investigate the association of cerebral SVD with CAVI in asymptomatic young and middle-aged subjects.
Asymptomatic Korean individuals aged 30 to 59 years old without neurologic disease who had CAVI and brain magnetic resonance imaging (MRI) were evaluated retrospectively.
Among 484 subjects, cerebral SVDs (advanced WML, SLI and CMB) were found in 20 (4.1%). Subjects with SVDs tended to be older and to have higher systolic blood pressure (SBP) and higher CAVI. From multivariate regression analysis, including pulse pressure (PP) or SBP, CAVI showed a significant association with SVD [adjusted OR (95% CI): 1.889 (1.094-3.263), p= 0.002 and 1.793 (1.020-3.153), p= 0.043, for PP and SBP, respectively]. When CAVI was assessed by quartiles, the highest quartile of CAVI (CAVI >7.65) showed a significant association with SVD, after adjustment for PP [adjusted OR (95% CI): 2.766 (1.115-6.866), p= 0.028].
In young and middle-aged subjects, cerebral SVD was significantly associated with arterial stiffness measured by CAVI after adjusting for PP or SBP.
心血管踝臂指数（CAVI）反映了从主动脉到脚踝的整体动脉僵硬度，与血压无关。脑小血管疾病（SVD），包括白质病变（WML）、无症状性腔隙性梗死（SLI）和脑微出血（CMB），被认为会进一步增加中风和认知障碍的风险。我们旨在研究无症状的年轻和中年人群中脑 SVD 与 CAVI 的相关性。
回顾性评估了年龄在 30 至 59 岁、无神经系统疾病且具有 CAVI 和脑磁共振成像（MRI）的无症状韩国个体。
在 484 名受试者中，发现了脑 SVD（高级 WML、SLI 和 CMB）20 例（4.1%）。有 SVD 的受试者年龄较大，收缩压（SBP）和 CAVI 较高。多元回归分析，包括脉压（PP）或 SBP，CAVI 与 SVD 显著相关[校正比值比（95%可信区间）：1.889（1.094-3.263），p=0.002 和 1.793（1.020-3.153），p=0.043，对于 PP 和 SBP 而言]。当按四分位数评估 CAVI 时，CAVI 的最高四分位数（CAVI>7.65）与 SVD 显著相关，在调整 PP 后[校正比值比（95%可信区间）：2.766（1.115-6.866），p=0.028]。
在年轻和中年人群中，在调整 PP 或 SBP 后，脑 SVD 与 CAVI 测量的动脉僵硬度显著相关。
