Lucchi M, Bilancini S
Centro Studi Malattie Vascolari, Frosinone, Italie.
J Mal Vasc. 1990;15(1):23-5.
The study concerned 7 subjects (3 men, 4 women) with nonfamilial antithrombin III deficit which, in the absence of known causes of acquired deficiency, was defined as "sporadic". Danazol (an attenuated synthetic androgen) already shown to be capable of compensating for a lack of certain antiproteases, was given in doses of 200 mg 3 times per day for 10 days, resulting in a rapid rise (mean 21.2%) in antithrombin III values. Unlike results reported in the literature in cases of familial antithrombin III deficit, the levels did not drop below their initial values despite discontinuance of the drug but unexpectedly remained high and even shows a slight subsequent rise. Although our study was limited to 11 cases, these data seem worthy of being reported, with the prospect of other confirmations concerning either this sort of "sporadic" antithrombin III deficit or the favorable effect of Danazol, even at long term.
该研究涉及7名非家族性抗凝血酶III缺乏症患者（3名男性，4名女性），在无已知获得性缺乏病因的情况下，这种缺乏症被定义为“散发性”。已证明能够补偿某些抗蛋白酶缺乏的达那唑（一种减毒合成雄激素），以每日3次、每次200毫克的剂量给药10天，导致抗凝血酶III值迅速升高（平均21.2%）。与文献报道的家族性抗凝血酶III缺乏症病例的结果不同，尽管停药，但水平并未降至初始值以下，反而出乎意料地保持在高位，甚至随后略有上升。尽管我们的研究仅限于11例病例，但这些数据似乎值得报告，有望得到关于这种“散发性”抗凝血酶III缺乏症或达那唑的有利作用（即使是长期作用）的其他证实。
