Fairfax A J, Ibbotson R M
Thorax. 1985 Sep;40(9):646-50. doi: 10.1136/thx.40.9.646.
Seven members of a family affected by hereditary antithrombin III deficiency were identified. The disorder was associated with recurrent spontaneous episodes of phlebitis, deep venous thrombosis, and pulmonary embolism in middle age. Danazol, a 17-alkyl derivative of ethinyl testosterone, which has been used to treat other antiprotease deficiency states, was assessed in the management of two men with antithrombin deficiency. In a dose of 600 mg a day danazol appeared to correct the antithrombin deficiency. This drug may provide a useful adjunct to anticoagulant treatment, particularly before surgery.
已确定一个受遗传性抗凝血酶III缺乏症影响的家族中的七名成员。该病症与中年时复发性静脉炎、深静脉血栓形成和肺栓塞的自发发作有关。达那唑是乙炔睾酮的17-烷基衍生物，已被用于治疗其他抗蛋白酶缺乏症，对两名抗凝血酶缺乏症男性的治疗进行了评估。每日剂量600毫克的达那唑似乎可纠正抗凝血酶缺乏。这种药物可能是抗凝治疗的有用辅助手段，尤其是在手术前。
