用于评估重组乙型肝炎PreS2+S疫苗接种者免疫反应的抗PreS2抗体检测
Anti-PreS2 antibody assay for evaluating immune responses among recipients of recombinant hepatitis B PreS2 + S vaccine.
作者信息
Hurni W M, Roehm R R, Miller W J
机构信息
Virus and Cell Biology Research, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania.
出版信息
J Med Virol. 1990 Feb;30(2):146-50. doi: 10.1002/jmv.1890300213.
PMID:2313274
Abstract
A competitive radioimmunoassay was developed for measuring hepatitis B virus (HBV) anti-PreS2 antibody. The assay has been demonstrated to be highly specific for anti-PreS2 antibody and not subject to interference by other antibodies to HBV-specific antigens. This assay was used to evaluate anti-PreS2 antibody responses in a hepatitis B PreS2 + S vaccine human clinical trial in healthy adults.
摘要
已开发出一种竞争性放射免疫测定法来检测乙型肝炎病毒（HBV）抗前S2抗体。该测定法已被证明对抗前S2抗体具有高度特异性，且不受其他针对HBV特异性抗原的抗体干扰。此测定法用于评估健康成年人中一项乙型肝炎前S2+S疫苗人体临床试验中的抗前S2抗体反应。
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