Andre P M, Le Pogamp P, Chevet D
Laboratory of Microbiology, University Hospital, Rennes, France.
J Clin Lab Anal. 1990;4(2):115-9. doi: 10.1002/jcla.1860040208.
A test was set up to analyze the direct binding of serum IgA to the lectin jacalin. Under the testing conditions, jacalin bound to both IgA subclasses and reacted similarly with monomeric and polymeric IgA. A jacalin index was defined to quantify serum IgA binding to this lectin. The jacalin index appeared significantly lower in IgA nephropathy than in controls. This may be related to abnormal IgA glycosylation, which could explain, at least in part, the mesangial deposition responsible for the renal disease.
建立了一项试验来分析血清IgA与凝集素红豆素的直接结合。在测试条件下，红豆素与两种IgA亚类结合，并且与单体和多聚体IgA反应相似。定义了红豆素指数以量化血清IgA与这种凝集素的结合。IgA肾病患者的红豆素指数显著低于对照组。这可能与IgA糖基化异常有关，这至少可以部分解释导致肾脏疾病的系膜沉积。
