[横纹肌收缩的简单动力学模型：肌节中肌丝完全重叠时的完全激活]
[A simple kinetic model of contraction of striated muscle: full activation at full filament overlap in sarcomeres].
作者信息
Sëmin F A, Tsaturian A K
出版信息
Biofizika. 2012 Sep-Oct;57(5):840-7.
PMID:23136777
Abstract
A simple kinetic model of muscle contraction is suggested. The rates of cross-bridge transitions from one kinetic state to another are supposed to depend on the averaged (over ensemble of actin-bound bridges) strain. With a proper set of the strain-dependent rates the model fits well a broad set of experimental data. Due to its simplicity, the relation between strain and stress is described by a set of ordinary differential equations; the model can be used for simulation of complex 3D muscle contraction.
摘要
提出了一个简单的肌肉收缩动力学模型。横桥从一种动力学状态转变为另一种动力学状态的速率被认为取决于（肌动蛋白结合桥的集合平均）应变。通过一组适当的应变相关速率，该模型很好地拟合了大量实验数据。由于其简单性，应变与应力之间的关系由一组常微分方程描述；该模型可用于模拟复杂的三维肌肉收缩。
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