Department of Preclinical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago.
Arch Physiol Biochem. 2013 Feb;119(1):22-6. doi: 10.3109/13813455.2012.735245. Epub 2012 Nov 9.
To assess the relationship of homocysteine, hs-CRP, with known cardiovascular risk factors of the metabolic syndrome.
Cross sectional study comprised 182 diabetic outpatients (70 males and 112 females), attending endocrinology clinics in Trinidad.
Both male and females showed significant linear relationships between high sensitive C-reactive protein (hs-CRP), blood pressure and diabetes (r = -0.2 < R or R > 0.2). In females hs-CRP showed significant linear relationship with HDL, triglyceride, blood pressure and diabetes mellitus (p < 0.0001). The inverse relationship of hs-CRP with HDL implies the strong association of hs-CRP with metabolic syndrome. The multivariate logistic regression analysis showed significant relation of hs-CRP, metabolic syndrome and diabetes mellitus. There was no significant relationship of tHCY to any of the features studied.
Serum C-reactive protein is significantly related to features of the metabolic syndrome. Total plasma homocysteine, appears to be independent of both hs-CRP and features of the metabolic syndrome.
评估同型半胱氨酸（HCY）、高敏 C 反应蛋白（hs-CRP）与代谢综合征已知心血管危险因素的关系。
横断面研究包括特立尼达的内分泌诊所的 182 例糖尿病门诊患者（70 名男性和 112 名女性）。
男性和女性的高敏 C 反应蛋白（hs-CRP）与血压和糖尿病均呈显著线性关系（r = -0.2<R 或 R>0.2）。在女性中，hs-CRP 与高密度脂蛋白（HDL）、甘油三酯、血压和糖尿病呈显著线性关系（p<0.0001）。hs-CRP 与 HDL 的负相关关系表明 hs-CRP 与代谢综合征密切相关。多元逻辑回归分析显示 hs-CRP、代谢综合征和糖尿病之间存在显著关系。总同型半胱氨酸（tHCY）与研究的任何特征均无显著关系。
血清 C 反应蛋白与代谢综合征的特征显著相关。总血浆同型半胱氨酸（HCY）似乎独立于 hs-CRP 和代谢综合征的特征。
