Jacobsen A B, Nesland J M, Fosså S D, Pettersen E O
Department of Tissue Culture, Norwegian Radium Hospital, Oslo.
J Urol. 1990 Apr;143(4):706-9. doi: 10.1016/s0022-5347(17)40066-8.
Biopsies from 64 patients with transitional cell carcinoma of the bladder (World Health Organization grade 3 and undifferentiated) were studied with deoxyribonucleic acid flow cytometry of fresh tissue and immunohistochemical staining on the histopathological slides for the presence of neuron specific enolase and human chorionic gonadotropin. No correlation was found among the presence of neuron specific enolase or human chorionic gonadotropin and T category, deoxyribonucleic acid ploidy, percentage of cells in the S phase, presence of metastatic disease or response to therapy. The prognosis for patients with muscle invasive disease and tumors positive for neuron specific enolase or human chorionic gonadotropin was similar to that for patients with tumors negative for these substances. When a possible new marker or prognostic factor is evaluated, it is important to investigate whether the new marker adds information on prognosis to what already is known by established standard methods. Further studies are needed to evaluate the clinical importance of human chorionic gonadotropin (and neuron specific enolase) as a marker in urothelial cancer with regard to prognosis and response to therapy.
对64例膀胱移行细胞癌（世界卫生组织3级及未分化型）患者的活检组织进行了新鲜组织的脱氧核糖核酸流式细胞术检测，并在组织病理学切片上进行免疫组织化学染色，以检测神经元特异性烯醇化酶和人绒毛膜促性腺激素的表达情况。未发现神经元特异性烯醇化酶或人绒毛膜促性腺激素的表达与T分期、脱氧核糖核酸倍体、S期细胞百分比、转移疾病的存在或治疗反应之间存在相关性。肌肉浸润性疾病且神经元特异性烯醇化酶或人绒毛膜促性腺激素阳性的肿瘤患者的预后与这些物质阴性的肿瘤患者相似。在评估一种可能的新标志物或预后因素时，重要的是要研究新标志物是否能为已有的标准方法所知晓的预后信息增添内容。需要进一步研究来评估人绒毛膜促性腺激素（以及神经元特异性烯醇化酶）作为尿路上皮癌标志物在预后和治疗反应方面的临床重要性。
