Berner A, Jacobsen A B, Fosså S D, Nesland J M
Department of Pathology, Norwegian Radium Hospital, Oslo.
Histopathology. 1993 Apr;22(4):327-33. doi: 10.1111/j.1365-2559.1993.tb00131.x.
Expression of c-erbB-2 protein, neuron-specific enolase (NSE) and DNA ploidy was studied by immunohistochemistry and flow cytometry in formalin-fixed and paraffin-embedded specimens from 104 patients with locally advanced transitional cell carcinoma of the bladder. Positive membrane bound c-erbB-2 staining was found in 15% of the tumours, and 38% of the tumours were positive for NSE. Only one tumour stained positively for both NSE and c-erbB-2. Expression of c-erbB-2 protein and NSE was neither correlated to tumour stage nor to histopathological grade. The frequency of non-diploid tumours was 78% in 49 c-erbB-2/NSE negative tumours, 98% in 40 NSE positive tumours, and 100% in 16 c-erbB-2 positive tumours (P = 0.004). Whether the c-erbB-2 expression is a useful prognostic marker in addition to other conventional parameters, remains to be shown.
采用免疫组织化学和流式细胞术，对104例局部晚期膀胱移行细胞癌患者经福尔马林固定、石蜡包埋的标本进行c-erbB-2蛋白、神经元特异性烯醇化酶（NSE）表达及DNA倍体分析。15%的肿瘤可见c-erbB-2膜染色阳性，38%的肿瘤NSE阳性。仅1例肿瘤NSE和c-erbB-2均呈阳性。c-erbB-2蛋白和NSE的表达与肿瘤分期及组织病理学分级均无相关性。49例c-erbB-2/NSE阴性肿瘤中非二倍体肿瘤的发生率为78%，40例NSE阳性肿瘤中为98%，16例c-erbB-2阳性肿瘤中为100%（P = 0.004）。c-erbB-2表达除其他传统参数外是否为有用的预后标志物，仍有待证实。
