Plant Jon D, Gortel Kinga, Kovalik Marcel, Polissar Nayak L, Neradilek Moni B
SkinVet Clinic, Lake Oswego, OR 97035, USA.
Vet Dermatol. 2012 Dec;23(6):515-e103. doi: 10.1111/j.1365-3164.2012.01113.x.
The third iteration of the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) is the only tool rigorously validated for canine atopic dermatitis (CAD) lesion scoring. The CADESI-03 requires 248 evaluations, limiting its widespread use.
HYPOTHESIS/OBJECTIVES: The goal of the study was to develop and validate a practical method of grading CAD lesions that requires scoring only the frequently affected body regions.
Fifty-seven privately owned atopic dogs were used in the study.
The Canine Atopic Dermatitis Lesion Index (CADLI) was evaluated in an open, multicentre reliability study. Validity was assessed with expert opinion (content validity) and comparison of CADLI with existing disease severity measures (construct and criterion validity). Reliability was evaluated by analysing repeated observations of each dog. Convenience was assessed in terms of the time required to complete the scale.
The CADLI scores correlated with overall assessment scores (r = 0.60, P < 0.001, linear mixed model) and pruritus severity scores (r = 0.53, P < 0.001, linear mixed model), establishing construct validity. The CADLI was strongly correlated with CADESI-03 (r = 0.84, P < 0.001, linear mixed model), establishing criterion validity. The CADLI values obtained by two observers correlated very strongly (r = 0.91, P < 0.001), as did the repeat values for the same observer (r = 0.98, P < 0.001). The mean time to complete the CADLI was less than that required for CADESI-03 (1.9 and 12.6 min, respectively), a highly significant difference (P < 0.001).
The CADLI was found to be an effective measure of CAD lesion severity, strongly correlating with CADESI-03. The convenience of CADLI makes it suitable for use in both clinical research and practice.
犬特应性皮炎范围和严重程度指数（CADESI - 03）的第三次修订版是唯一经过严格验证的用于犬特应性皮炎（CAD）皮损评分的工具。CADESI - 03需要进行248次评估，限制了其广泛应用。
假设/目标：本研究的目的是开发并验证一种实用的CAD皮损分级方法，该方法仅需对经常受累的身体部位进行评分。
57只私人饲养的特应性犬用于本研究。
在一项开放性多中心可靠性研究中对犬特应性皮炎皮损指数（CADLI）进行评估。通过专家意见评估效度（内容效度），并将CADLI与现有疾病严重程度指标进行比较评估效度（结构效度和标准效度）。通过分析对每只犬的重复观察来评估信度。根据完成该量表所需时间评估便利性。
CADLI评分与总体评估评分相关（r = 0.60，P < 0.001，线性混合模型）以及瘙痒严重程度评分相关（r = 0.53，P < 0.001，线性混合模型），确立了结构效度。CADLI与CADESI - 03高度相关（r = 0.84，P < 0.001，线性混合模型），确立了标准效度。两位观察者获得的CADLI值相关性非常强（r = 0.9,1，P < 0.001），同一观察者的重复值也是如此（r = 0.98，P < 0.001）。完成CADLI的平均时间少于CADESI - 03所需时间（分别为1.9分钟和12.6分钟），差异极显著（P < 0.001）。
发现CADLI是一种有效的CAD皮损严重程度测量方法，与CADESI - 03高度相关。CADLI的便利性使其适用于临床研究和实践。
