临床研究中使用的三种方法对低血铅浓度的质量控制数据。
Quality control data for low blood lead concentrations by three methods used in clinical studies.
作者信息
Osterloh J D, Sharp D S, Hata B
机构信息
Department of Medicine, University of California, San Francisco.
出版信息
J Anal Toxicol. 1990 Jan-Feb;14(1):8-11. doi: 10.1093/jat/14.1.8.
During several clinical studies of blood lead (BPb) concentrations from environmental exposure, quality control data for three different methods of BPb analysis were compiled. Anodic stripping voltammetry by a commercial method (cASV), a modified method (mASV), and graphite furnace atomic absorption spectrophotometry (GFAA) were compared for precision at low BPb concentrations (less than 25 micrograms/dL) analyses. Both duplicate and interassay precision, as well as direct determinations of intraassay precision, were less for GFAA. The mASV incorporated calibration with lower BPb standards than used in the commercial protocol. This appeared to correct nonlinearity in response at lower BPb and reduced the bias between ASV and GFAA at BPb concentrations typical of environmental exposure levels.
在几项关于环境暴露导致的血铅（BPb）浓度的临床研究中，汇编了三种不同BPb分析方法的质量控制数据。比较了商业方法的阳极溶出伏安法（cASV）、改良方法（mASV）和石墨炉原子吸收光谱法（GFAA）在低BPb浓度（低于25微克/分升）分析时的精密度。GFAA的重复和批间精密度以及批内精密度的直接测定值均较低。mASV采用了比商业方案中使用的更低BPb标准进行校准。这似乎纠正了较低BPb时响应的非线性，并减少了在环境暴露水平典型的BPb浓度下ASV和GFAA之间的偏差。
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