European Centre for Environment and Human Health, Exeter Medical School, University of Exeter, Truro, Cornwall, UK.
Mar Environ Res. 2013 Feb;83:93-5. doi: 10.1016/j.marenvres.2012.10.003. Epub 2012 Oct 29.
Thousands of toxic chemicals, many of which pollute marine ecosystems, potentially cause diseases, but building a consensus view of the significance of human body burdens of environmental chemicals is proving difficult. Causative mechanisms are often lacking. Older members of the population, of which there are increasing numbers worldwide, accumulate higher body burdens than the young, and may be especially at risk. It also remains unclear when crucially sensitive periods for chemical exposures occur across the life course. Very early exposures may lead to diseases much later on. The current lack of robust science upon which to base high quality expert advice is hampering effective policymaking that leads to further reductions in marine pollution, greater protection of marine life and lowering of risks to human health.
数以千计的有毒化学物质，其中许多污染海洋生态系统，可能导致疾病，但要达成对人体环境化学物负荷重要性的共识观点却非常困难。其致病机制往往并不明确。全球范围内，老年人口数量不断增加，他们体内的化学物负荷比年轻人更高，而且可能面临更高的风险。在整个生命周期中，化学物质暴露的关键敏感时期何时出现也尚不清楚。早期暴露可能会导致很久以后才出现疾病。目前，缺乏可靠的科学依据来提供高质量的专家建议，这阻碍了有效的决策制定，无法进一步减少海洋污染、更好地保护海洋生物以及降低人类健康风险。
