帕金森病患者临床特征与夜间心脏自主神经活动的关系。
Relationships between clinical characteristics and nocturnal cardiac autonomic activity in Parkinson's disease.
机构信息
Department of General Psychology, University of Padova, Italy.
出版信息
Auton Neurosci. 2012 Nov 2;171(1-2):85-8. doi: 10.1016/j.autneu.2012.10.003. Epub 2012 Nov 8.
Abstract
BACKGROUND
The aim of the present study was to explore the association between Parkinson's disease (PD) clinical characteristics and cardiac autonomic control across sleep stages.
METHODS
Frequency-domain heart rate variability (HRV) measures were estimated in 18 PD patients undergoing a night of polysomnography.
RESULTS
Significant relationships were found between PD severity and nocturnal HRV indices. The associations were restricted to rapid eye movement (R) sleep.
CONCLUSIONS
The progressive nocturnal cardiac autonomic impairment occurring with more severe PD can be subclinical emerging only during conditions requiring active modulation of physiological functions such as R-sleep.
摘要
背景
本研究旨在探讨帕金森病（PD）临床特征与睡眠各期心脏自主控制之间的关系。
方法
对 18 例接受多导睡眠图检查的 PD 患者进行了频域心率变异性（HRV）测量。
结果
PD 严重程度与夜间 HRV 指标之间存在显著关系。这些关联仅限于快速眼动（R）睡眠。
结论
随着 PD 病情的加重，夜间心脏自主功能逐渐受损，这种亚临床损害仅在需要主动调节生理功能的情况下出现，如 R 睡眠。
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