帕金森病睡眠中周期性肢体运动的临床相关性。
Clinical correlates of periodic limb movements in sleep in Parkinson's disease.
机构信息
Department of General Psychology, University of Padova, Italy.
出版信息
J Neurol Sci. 2012 May 15;316(1-2):131-6. doi: 10.1016/j.jns.2012.01.004. Epub 2012 Jan 25.
OBJECTIVE
The aim of the current study was to investigate the frequency of periodic limb movements in sleep (PLMS) in Parkinson's disease (PD) and their impact on nocturnal sleep and daytime functioning.
METHODS
Forty-five PD patients (mean age 68.5 ± 8.7 years; 32 males) underwent one night of polysomnography (PSG). Clinical assessment and questionnaires evaluating sleep disturbance and quality of life (QoL) were completed. Patients were divided into two groups based on their PLMS index (PLMSI): PLMSI ≥ 15 (PLMS+) and PLMSI <15 (PLMS-).
RESULTS
There were 26 (57.8%) PD patients in the PLMS+group and 19 (42.2%) patients in the PLMS-group. Subjective assessment revealed an association between PLMS+status and greater PD symptom severity, more subjective sleep disturbance, and decreased QoL. All patients showed poor sleep, and no significant group differences were detected on PSG measures.
CONCLUSION
We observed that PLMS occurred frequently in PD and increased with more severe PD. Although PLMS did not affect objective sleep, it was associated with increased sleep complaints and reduced QoL. Overall, our findings support the association between PLMS and PD as well as the clinical relevance of sleep disturbances in PD.
目的
本研究旨在探讨帕金森病（PD）患者睡眠周期性肢体运动（PLMS）的频率及其对夜间睡眠和日间功能的影响。
方法
45 例 PD 患者（平均年龄 68.5±8.7 岁；32 名男性）进行了一夜多导睡眠图（PSG）检查。完成了临床评估和评估睡眠障碍和生活质量（QoL）的问卷。根据他们的 PLMS 指数（PLMSI）将患者分为两组：PLMSI≥15（PLMS+）和 PLMSI<15（PLMS-）。
结果
PLMS+组有 26 例（57.8%）PD 患者，PLMS-组有 19 例（42.2%）患者。主观评估显示，PLMS+状态与 PD 症状严重程度增加、更多的主观睡眠障碍和 QoL 下降有关。所有患者的睡眠质量均较差，PSG 测量结果无显著组间差异。
结论
我们观察到 PLMS 在 PD 中频繁发生，并随 PD 加重而增加。虽然 PLMS 不影响客观睡眠，但与睡眠主诉增加和 QoL 下降有关。总的来说，我们的研究结果支持 PLMS 与 PD 之间的关联，以及 PD 中睡眠障碍的临床相关性。
Zotero 插件