Aleksander S K, Fidler L M, Pugachev K K, Revazova E S, Avdeev G I
Med Radiol (Mosk). 1990 Feb;35(2):25-8.
Radioactive iodine-labeled rabbit antibodies to beta 1-MA antigen (the marker of human colon cancer) were injected iv to BALB/c mice as well as to nude mice with xenografts of various human tumors. Preparations of iodinated antibodies contained an admixture of protein-unbound radionuclide 2-4% of total radioactivity. Part of the recipient animals were given per os 0.1% solution of KI to block the thyroid from radioactive iodine. A comparative study was made of the distribution of radioactivity in the tissues of recipients in the time course of 7 days. The thyroid of nude mice with tumors was shown to uptake much more radioactivity than that of immunologically intact mice. In addition to its protective effect of the thyroid from radioactive iodine, KI also enhanced the excretion of the preparation of labeled antibodies. Possible mechanisms of the revealed phenomena were analyzed.
将放射性碘标记的抗β1 - MA抗原（人类结肠癌标志物）兔抗体静脉注射到BALB/c小鼠以及患有各种人类肿瘤异种移植瘤的裸鼠体内。碘化抗体制剂中含有占总放射性2 - 4%的未与蛋白质结合的放射性核素混合物。部分受体动物经口给予0.1%的KI溶液以阻止甲状腺摄取放射性碘。对受体动物组织中放射性在7天时间进程内的分布进行了比较研究。结果显示，患有肿瘤的裸鼠甲状腺摄取的放射性比免疫健全小鼠的甲状腺多得多。KI除了对甲状腺有保护作用使其免受放射性碘影响外，还增强了标记抗体制剂的排泄。分析了所揭示现象的可能机制。
