烯丙基二氟化物与酰胺和硫醇盐的 S(N)2'反应。
S(N)2' reaction of allylic difluorides with lithium amides and thiolates.
机构信息
Canada Research Chair in Organic and Medicinal Chemistry, Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, Québec G1V 0A6, Canada.
出版信息
Org Lett. 2012 Dec 7;14(23):5888-91. doi: 10.1021/ol302802r. Epub 2012 Nov 12.
PMID:23145465
Abstract
The synthesis of monofluoroalkenes using an S(N)2' reaction of lithium amides derived from aromatic amines or lithium thiolates with 3,3-difluoropropenes is reported. This transformation features the use of fluoride as a leaving group.
摘要
本文报道了通过芳胺或硫醇锂衍生的酰胺与 3,3-二氟丙烯的 S(N)2' 反应合成单氟烯烃。该转化使用氟化物作为离去基团。
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