通过可见光诱导的三氟甲基芳基化/1,4-芳基迁移/脱磺酰化串联反应实现烯烃的双官能化
Difunctionalization of Alkenes via the Visible-Light-Induced Trifluoromethylarylation/1,4-Aryl Shift/Desulfonylation Cascade Reactions.
作者信息
Zheng Lewei, Yang Chao, Xu ZhaoZhong, Gao Fei, Xia Wujiong
机构信息
State Key Lab of Urban Water Resource and Environment, the Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Harbin 150080, China.
出版信息
J Org Chem. 2015 Jun 5;80(11):5730-6. doi: 10.1021/acs.joc.5b00677. Epub 2015 May 19.
A novel visible-light-induced trifluoromethylarylation/1,4-aryl shift/desulfonylation cascade reaction using CF3SO2Cl as CF3 source was described. The protocol provides an efficient approach for the synthesis of α-aryl-β-trifluoromethyl amides and/or CF3-containing oxindoles as well as the isoquinolinediones under benign conditions.
报道了一种使用CF3SO2Cl作为CF3源的新型可见光诱导的三氟甲基芳基化/1,4-芳基迁移/脱磺酰化串联反应。该方法为在温和条件下合成α-芳基-β-三氟甲基酰胺和/或含CF3的氧化吲哚以及异喹啉二酮提供了一种有效的途径。
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