Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
J Am Chem Soc. 2013 Sep 4;135(35):12990-3. doi: 10.1021/ja407223g. Epub 2013 Aug 20.
The first catalytic allylic C-H fluorination reaction using a nucleophilic fluoride source is reported. Under the influence of a Pd/Cr cocatalyst system, simple olefin substrates undergo fluorination with Et3N·3HF in good yields with high branched:linear regioselectivity. The mild conditions and broad scope make this reaction a powerful alternative to established methods for the preparation of allylic fluorides from prefunctionalized substrates.
首次报道了使用亲核氟源的催化烯丙基 C-H 氟化反应。在 Pd/Cr 共催化剂体系的影响下，简单的烯烃底物与 Et3N·3HF 反应，以高支化:线性区域选择性得到良好收率的氟化产物。温和的条件和广泛的适用范围使该反应成为从预官能化底物制备烯丙基氟化物的已有方法的有力替代方法。
