Leppik I E, Boucher B A, Wilder B J, Murthy V S, Watridge C, Graves N M, Rangel R J, Rask C A, Turlapaty P
Department of Neurology, University of Minnesota, Minneapolis 55414.
Neurology. 1990 Mar;40(3 Pt 1):456-60. doi: 10.1212/wnl.40.3_part_1.456.
ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.
ACC - 9653是一种为具备水溶性而合成的苯妥英前体药物，可通过磷酸酶转化为苯妥英。在本研究中，43名患者接受了静脉注射或肌肉注射ACC - 9653。副作用短暂且轻微。静脉注射和肌肉注射后ACC - 9653的转化半衰期平均分别为8.4分钟和32.7分钟。苯妥英的峰值浓度在静脉注射后42分钟出现，在肌肉注射后151分钟出现。
