通过银（I）促进的半缩醛烷基化反应进行对映选择性合成螺缩醛：头孢菌素 E 和 F 的全合成。
Enantioselective synthesis of spiroacetals via silver(I)-promoted alkylation of hemiacetals: total synthesis of cephalosporolides E and F.
机构信息
Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
出版信息
Org Lett. 2012 Dec 7;14(23):5844-7. doi: 10.1021/ol302694s. Epub 2012 Nov 12.
PMID:23145960
Abstract
A silver(I)-promoted intramolecular hemiacetal alkylation has been developed that converts readily available keto-chlorodiols into functionalized spiroacetals containing 5,5-, 5,6-, and 5,7-membered ring systems. The efficiency of this process is demonstrated in a concise total synthesis of the fungal metabolites cephalosporolides E and F.
摘要
一种银（I）促进的分子内环半缩醛烷基化反应已经被开发出来，该反应可以将易得的酮-氯代二醇转化为含有 5,5-、5,6-和 5,7 元环系统的功能化螺缩醛。该过程的效率在真菌代谢产物头孢菌素 E 和 F 的简洁全合成中得到了证明。
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