一家肾移植中心的耶氏肺孢子菌肺炎疫情：T细胞淋巴细胞减少症的作用。
An epidemic of Pneumocystis jiroveci pneumonia in a renal transplantation center: role of T-cell lymphopenia.
作者信息
Brunot V, Pernin V, Chartier C, Garrigue V, Vetromile F, Szwarc I, Delmas S, Portalès P, Basset D, Mourad G
机构信息
Department of Nephrology and Transplantation, Hôpital Lapeyronie, University of Montpellier, Montpellier, France.
出版信息
Transplant Proc. 2012 Nov;44(9):2818-20. doi: 10.1016/j.transproceed.2012.09.089.
Although only 2 cases of Pneumocystis jiroveci pneumonia were observed in our center between 2004 and 2009, we diagnosed 9 cases in 2010. Each patient had been in contact in the hospital with at least 1 other patient suffering P jiroveci pneumonia. Genotyping of P jiroveci pneumonia strains demonstrates a total homogeneity of the DNA sequences in the 7 patients already analyzed. CD4+ lymphocyte count was significantly lower at M3 in P jiroveci pneumonia patients than in controls. Our clinical and molecular data confirm that interhuman transmission of P jiroveci is possible, particularly to lymphopenic transplant recipients.
尽管2004年至2009年间我们中心仅观察到2例耶氏肺孢子菌肺炎病例，但在2010年我们诊断出9例。每位患者在医院里都曾与至少1例患有耶氏肺孢子菌肺炎的其他患者有过接触。对耶氏肺孢子菌肺炎菌株的基因分型显示，在已分析的7例患者中DNA序列完全相同。耶氏肺孢子菌肺炎患者在M3时的CD4 +淋巴细胞计数显著低于对照组。我们的临床和分子数据证实，耶氏肺孢子菌人际传播是可能的，尤其是对淋巴细胞减少的移植受者。
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