Kanwal Sandeep Kumar, Yadav Dinesh, Chhapola Viswas, Kumar Virendra
Department of Paediatrics, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital, New Delhi, India.
Trop Doct. 2012 Oct;42(4):195-7. doi: 10.1258/td.2012.120293. Epub 2012 Nov 12.
A retrospective study was done on 48 consecutive patients with clinical diagnosis of post-diphtheritic neuropathy admitted to the paediatric intensive care unit of tertiary care hospital in North India between January 2008 and December 2010 to study the clinical profile of post-diphtheritic neuropathy in children. The case records were reviewed and information regarding personal details, clinical features, recovery parameters and outcome was recorded using a predesigned proforma. Median age was 4.25 years. All cases were unimmunized. Median latency period was 15 days. Of the children, 52% had palatal palsy whereas 48% had limb weakness initially. Median duration of progression of weakness was five days. Limb muscle weakness was present in 94%. Respiratory muscles were involved in 85.4% cases and 60.4% required mechanical ventilation, while 14.6% had fatal outcome and 10.4% had hypoxic neurological injury. Boys were affected more. Median duration of latency was shorter; muscle weakness, progression and recovery were faster as compared with observational studies in adults.
对2008年1月至2010年12月期间入住印度北部一家三级医院儿科重症监护病房的48例临床诊断为白喉后神经病变的连续患者进行了一项回顾性研究，以研究儿童白喉后神经病变的临床特征。查阅病例记录，并使用预先设计的表格记录有关个人详细信息、临床特征、恢复参数和结果的信息。中位年龄为4.25岁。所有病例均未接种疫苗。中位潜伏期为15天。在这些儿童中，52%最初出现腭麻痹，而48%最初出现肢体无力。无力进展的中位持续时间为5天。94%的儿童存在肢体肌肉无力。85.4%的病例呼吸肌受累，60.4%的病例需要机械通气，14.6%的病例有致命结局，10.4%的病例有缺氧性神经损伤。男孩受影响更多。与成人的观察性研究相比，中位潜伏期较短；肌肉无力、进展和恢复较快。
