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Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region.

作者信息

Gao Haishan, Wu Xiaojing, Chai Jijie, Han Zhifu

出版信息

Cell Res. 2012 Dec;22(12):1716-20. doi: 10.1038/cr.2012.156. Epub 2012 Nov 13.

Abstract
摘要

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Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease.
Mol Biosyst. 2012 Apr;8(4):1255-63. doi: 10.1039/c2mb05461b. Epub 2012 Feb 3.
2
Structural basis for sequence-specific recognition of DNA by TAL effectors.
Science. 2012 Feb 10;335(6069):720-3. doi: 10.1126/science.1215670. Epub 2012 Jan 5.
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The crystal structure of TAL effector PthXo1 bound to its DNA target.
Science. 2012 Feb 10;335(6069):716-9. doi: 10.1126/science.1216211. Epub 2012 Jan 5.
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TALEs of genome targeting.
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De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks.
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2623-8. doi: 10.1073/pnas.1019533108. Epub 2011 Jan 24.
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Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription.
Nat Biotechnol. 2011 Feb;29(2):149-53. doi: 10.1038/nbt.1775. Epub 2011 Jan 19.
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TAL effectors are remote controls for gene activation.
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