内分泌和代谢急症：高钙血症。
Endocrine and metabolic emergencies: hypercalcaemia.
机构信息
Glenn Matfin, MSc (Oxon), MB ChB, FFPM, FACE, FACP, FRCP Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA; and Division of Endocrinology, New York University School of Medicine New York, NY, USA.
出版信息
Ther Adv Endocrinol Metab. 2010 Oct;1(5):225-34. doi: 10.1177/2042018810390260.
Abstract
Hypercalcaemia is commonly seen in the context of parathyroid dysfunction and malignancy and, when severe, can precipitate Life-threatening sequelae. The differential of hypercalcaemia is broad and can be categorized based on parathyroid hormone (PTH) Levels. The acute management of severe hypercalcaemia is discussed along with a brief review of therapeutic advances in the field.
摘要
高钙血症常见于甲状旁腺功能紊乱和恶性肿瘤，严重时可导致危及生命的并发症。高钙血症的鉴别诊断范围广泛，可以根据甲状旁腺激素 (PTH) 水平进行分类。本文讨论了严重高钙血症的急性处理方法，并简要回顾了该领域的治疗进展。
相似文献
1
Endocrine and metabolic emergencies: hypercalcaemia.内分泌和代谢急症：高钙血症。
Ther Adv Endocrinol Metab. 2010 Oct;1(5):225-34. doi: 10.1177/2042018810390260.
2
Parathyroid hormone and parathyroid hormone-related protein in the investigation of hypercalcaemia in two hospital populations.甲状旁腺激素和甲状旁腺激素相关蛋白在两家医院人群高钙血症调查中的应用
Clin Endocrinol (Oxf). 1994 Oct;41(4):407-13. doi: 10.1111/j.1365-2265.1994.tb02569.x.
3
Survival in hypercalcaemic patients with cancer and co-existing primary hyperparathyroidism.患有癌症且并存原发性甲状旁腺功能亢进的高钙血症患者的生存率。
Postgrad Med J. 1995 Jan;71(831):28-31. doi: 10.1136/pgmj.71.831.28.
4
Parathyroid carcinoma with pancreatitis causing hypercalcaemic emergency treated with extracorporeal membrane oxygenation-assisted parathyroid resection.甲状旁腺癌合并胰腺炎导致高钙血症危象，采用体外膜肺氧合辅助甲状旁腺切除术治疗。
Endocrinol Diabetes Metab Case Rep. 2023 Jan 5;2023(1):22-0323. doi: 10.1530/EDM-22-0323.
5
A clinical perspective of parathyroid hormone related hypercalcaemia.甲状旁腺激素相关高钙血症的临床观察。
Rev Endocr Metab Disord. 2020 Mar;21(1):77-88. doi: 10.1007/s11154-019-09529-5.
6
Acute kidney injury associated with hypercalcaemic crisis in a patient with primary hyperparathyroidism.原发性甲状旁腺功能亢进患者中与高钙血症危象相关的急性肾损伤。
BMJ Case Rep. 2018 Jul 30;2018:bcr-2018-225235. doi: 10.1136/bcr-2018-225235.
7
Primary hyperparathyroidism or hypercalcaemia of malignancy?
Scand J Clin Lab Invest. 1992 Jun;52(4):347-9. doi: 10.1080/00365519209088368.
8
Severe hypercalcaemia of primary hyperparathyroidism: Could giant adenoma be the real culprit rather than carcinoma?原发性甲状旁腺功能亢进症的严重高钙血症：真正的罪魁祸首会是巨大腺瘤而非癌吗？
Ann R Coll Surg Engl. 2020 May;102(5):363-368. doi: 10.1308/rcsann.2020.0039. Epub 2020 Apr 1.
9
Clinicopathological peculiarities in parathyroid disease with hypercalcaemic crisis.伴有高钙血症危象的甲状旁腺疾病的临床病理特点
Eur J Surg. 1993 Nov-Dec;159(11-12):613-7.
10
Circulating levels of midregional parathyroid hormone-related protein in hypercalcaemia of malignancy.恶性肿瘤高钙血症时血循环中中段甲状旁腺激素相关蛋白的水平
Clin Endocrinol (Oxf). 1992 Sep;37(3):290-7. doi: 10.1111/j.1365-2265.1992.tb02324.x.
引用本文的文献
1
Uric Acid in Primary Hyperparathyroidism: Marker, Consequence, or Bystander?原发性甲状旁腺功能亢进症中的尿酸：标志物、后果还是旁观者？
Metabolites. 2025 Jul 2;15(7):444. doi: 10.3390/metabo15070444.
2
A Rare Manifestation of Unknown Hyperparathyroidism as a Perforated Peptic Ulcer.不明原因甲状旁腺功能亢进的罕见表现为消化性溃疡穿孔。
Cureus. 2023 Apr 16;15(4):e37635. doi: 10.7759/cureus.37635. eCollection 2023 Apr.
3
Renal sarcoidosis presenting with hypercalcemia, acute kidney injury and proteinuria. Lesson for the clinical nephrologist.以高钙血症、急性肾损伤和蛋白尿为表现的肾结节病。给临床肾病学家的经验教训。
J Nephrol. 2023 Mar;36(2):307-310. doi: 10.1007/s40620-022-01501-y. Epub 2022 Nov 9.
4
[The clinical practice guidelines for primary hyperparathyroidism, short version].[原发性甲状旁腺功能亢进症临床实践指南，简版]
Probl Endokrinol (Mosk). 2021 Aug 19;67(4):94-124. doi: 10.14341/probl12801.
5
The Unforeseen Diagnosis: Hyperparathyroidism-Jaw Tumour Syndrome Case Report and Review of the Literature.意外诊断：甲状旁腺功能亢进-颌骨肿瘤综合征病例报告及文献综述
Case Rep Endocrinol. 2021 May 20;2021:5551203. doi: 10.1155/2021/5551203. eCollection 2021.
6
Neurological Complications of Endocrine Emergencies.内分泌急症的神经系统并发症。
Curr Neurol Neurosci Rep. 2021 Mar 11;21(5):21. doi: 10.1007/s11910-021-01105-2.
7
High-dose versus low-dose ergocalciferol for correcting hypovitaminosis D after fragility hip fracture: a randomized controlled trial.大剂量与小剂量骨化三醇纠正脆性髋部骨折后维生素 D 缺乏症的随机对照试验。
BMC Geriatr. 2021 Jan 21;21(1):72. doi: 10.1186/s12877-021-02023-1.
8
A rare case of hypercalcemic encephalopathy from ectopic secretion of parathyroid hormone.一例罕见的因异位分泌甲状旁腺激素导致的高钙血症性脑病。
Clin Case Rep. 2020 Jan 25;8(3):423-425. doi: 10.1002/ccr3.2631. eCollection 2020 Mar.
9
Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease.肾上腺危象表现为一名部分性垂体功能减退和透析前慢性肾脏病患者因急性肾盂肾炎引发的高钙血症和低钠血症急性发作。
CEN Case Rep. 2019 May;8(2):83-88. doi: 10.1007/s13730-018-0371-9. Epub 2018 Nov 19.
10
Calcitriol-mediated hypercalcemia secondary to granulomatous disease caused by soft-tissue filler injection: a case report.软组织填充剂注射所致肉芽肿病继发骨化三醇介导的高钙血症：一例报告
Clin Cases Miner Bone Metab. 2017 Sep-Dec;14(3):340-346. doi: 10.11138/ccmbm/2017.14.3.340. Epub 2017 Dec 27.
本文引用的文献
1
New perspectives in the management of primary hyperparathyroidism.原发性甲状旁腺功能亢进症的治疗新视角。
Ther Adv Endocrinol Metab. 2010 Oct;1(5):197-205. doi: 10.1177/2042018810382326.
2
Endocrine and metabolic emergencies: hypocalcaemia.内分泌和代谢急症：低钙血症。
Ther Adv Endocrinol Metab. 2010 Feb;1(1):29-33. doi: 10.1177/2042018810366494.
3
Parathyroidectomy for hypercalcemic crisis: 40 years' experience and long-term outcomes.甲状旁腺切除术治疗高钙血症危象：40 年经验和长期结果。
Surgery. 2010 Oct;148(4):807-12; discussion 812-3. doi: 10.1016/j.surg.2010.07.041. Epub 2010 Aug 30.
4
Medical applications and toxicities of gallium compounds.镓化合物的医学应用和毒性。
Int J Environ Res Public Health. 2010 May;7(5):2337-61. doi: 10.3390/ijerph7052337. Epub 2010 May 10.
5
Investigation of incidental hypercalcaemia.偶发性高钙血症的调查
BMJ. 2009 Nov 20;339:b4613. doi: 10.1136/bmj.b4613.
6
Therapeutic implications of osteoprotegerin.骨保护素的治疗意义
Cancer Cell Int. 2009 Sep 12;9:26. doi: 10.1186/1475-2867-9-26.
7
Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure.地舒单抗对有和无既往双膦酸盐暴露的骨转移患者的疗效。
J Bone Miner Res. 2010 Mar;25(3):440-6. doi: 10.1359/jbmr.090810.
8
Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism.西那卡塞可降低难治性原发性甲状旁腺功能亢进患者的血清钙浓度。
J Clin Endocrinol Metab. 2009 Aug;94(8):2766-72. doi: 10.1210/jc.2008-2640. Epub 2009 May 26.
9
Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice.抗甲状旁腺激素相关蛋白抗体联合唑来膦酸强化治疗重症联合免疫缺陷小鼠小细胞肺癌细胞骨转移
Mol Cancer Ther. 2009 Jan;8(1):119-26. doi: 10.1158/1535-7163.MCT-08-0874.
10
Narrative review: furosemide for hypercalcemia: an unproven yet common practice.叙述性综述：速尿治疗高钙血症：一种未经证实但常见的做法。
Ann Intern Med. 2008 Aug 19;149(4):259-63. doi: 10.7326/0003-4819-149-4-200808190-00007.
Zotero 插件