Department of Epidemiology and Community Health, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0212, United States.
J Psychosom Res. 2012 Dec;73(6):418-23. doi: 10.1016/j.jpsychores.2012.09.018. Epub 2012 Oct 23.
Depression is increasingly recognized as a risk factor for type 2 diabetes, and is also commonly comorbid with anxiety. However, few studies have examined whether anxiety is predictive of diabetes risk. The objectives of this study are to examine the prospective relationship between anxiety disorders (generalized anxiety disorder, panic disorder, social phobia, and agoraphobia) and risk of type 2 diabetes over an 11-year period, and to investigate the association between anxiety and risk of diabetes-related complications among those with prevalent type 2 diabetes.
Data come from the 1993/6 and 2004/5 waves of the Baltimore Epidemiologic Catchment Area Study (N=1920), a population-based prospective cohort. Anxiety disorders were assessed using the Diagnostic Interview Schedule. The prospective association between anxiety and incident type 2 diabetes was evaluated using a series of nested multivariable logistic regression models.
At baseline, 315 participants (21.8%) had an anxiety disorder. The relationship between anxiety and risk of developing type 2 diabetes was not statistically significant after controlling for demographic characteristics (Odds Ratio (OR): 1.28, 95% Confidence Interval (CI): 0.75, 2.18). There was no relationship between anxiety and diabetes risk after controlling for health behaviors and depression status (OR: 1.00, 95% CI: 0.53, 1.89). There was no significant relationship between anxiety and development of diabetes-related complications among those with prevalent type 2 diabetes (OR: 2.02, 95% CI: 0.61, 6.74).
Anxiety disorders are not associated with increased risk of type 2 diabetes or risk of diabetes complications among those who have diabetes.
抑郁逐渐被认为是 2 型糖尿病的一个风险因素，同时也常与焦虑共病。然而，很少有研究探讨焦虑是否可以预测糖尿病风险。本研究旨在探讨在 11 年期间，焦虑障碍（广泛性焦虑障碍、惊恐障碍、社交恐惧症和广场恐怖症）与 2 型糖尿病风险之间的前瞻性关系，并调查在已确诊 2 型糖尿病患者中，焦虑与糖尿病相关并发症风险之间的关联。
数据来自基于人群的前瞻性队列研究——巴尔的摩流行病学抽样区研究的 1993/6 年和 2004/5 年波次（N=1920）。使用诊断访谈量表评估焦虑障碍。采用一系列嵌套多变量逻辑回归模型评估焦虑与新发 2 型糖尿病之间的前瞻性关联。
在基线时，315 名参与者（21.8%）患有焦虑障碍。在控制人口统计学特征后，焦虑与发展为 2 型糖尿病的关系不具有统计学意义（优势比（OR）：1.28，95%置信区间（CI）：0.75，2.18）。在控制健康行为和抑郁状态后，焦虑与糖尿病风险之间没有关系（OR：1.00，95% CI：0.53，1.89）。在已确诊 2 型糖尿病患者中，焦虑与糖尿病相关并发症的发展之间没有显著关系（OR：2.02，95% CI：0.61，6.74）。
焦虑障碍与 2 型糖尿病风险增加或已确诊糖尿病患者的糖尿病并发症风险无关。
