Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey.
Ann Endocrinol (Paris). 2012 Dec;73(6):542-5. doi: 10.1016/j.ando.2012.09.008. Epub 2012 Nov 10.
The present study aimed to investigate the effect of smoking on thyroid nodule formation and goiter development in healthy subjects living in Istanbul, an iodine-sufficient region. This study was designed as a prospective, randomized, and observational study.
Included in the study were voluntary hospital staff and relatives of patients between the ages of 28 and 71 who had no known disease or drug use, who have been living in Istanbul and had been smoking more than 10 cigarettes per day for at least 10years. Nonsmoker volunteers (45) shared similar demographic characteristics and were matched for age to the (46) smokers. By means of thyroid ultrasounds performed in all participants, volumes of the right and left lobes of the thyroid gland, and number, diameter and characteristics of nodules were evaluated.
Comparing the smokers and nonsmokers, no statistically significant difference was determined in terms of presence of nodules and volumes of the left and right thyroid lobes (P=0.68, P=0.09, and P=0.63, respectively). Making enhanced diffuse enlargement of the thyroid gland, but not to a statistically significant degree. Smoking was observed to have no effect on non-toxic nodules, or the levels of thyroid-stimulating hormone, free thyroxin, free triiodothyronine, anti-thyroid peroxidase, or anti-thyroglobulin antibodies.
Smoking does not effect, to a statistically significant degree goiter development thyroid nodule formation in iodine-sufficient regions like Istanbul.
本研究旨在探讨吸烟对居住在碘充足地区伊斯坦布尔的健康受试者甲状腺结节形成和甲状腺肿发展的影响。本研究设计为前瞻性、随机和观察性研究。
研究纳入了年龄在 28 至 71 岁之间的自愿性医院工作人员和患者亲属，他们没有已知疾病或药物使用史，居住在伊斯坦布尔，并且每天至少吸烟 10 支，吸烟史超过 10 年。45 名非吸烟者志愿者与年龄匹配的（46）吸烟者具有相似的人口统计学特征。通过对所有参与者进行甲状腺超声检查，评估甲状腺右叶和左叶的体积、结节的数量、直径和特征。
比较吸烟者和非吸烟者，在结节存在和左、右甲状腺叶体积方面均未发现统计学显著差异（P=0.68、P=0.09 和 P=0.63）。但观察到甲状腺弥漫性肿大增强，但未达到统计学显著程度。吸烟对无毒结节或甲状腺刺激激素、游离甲状腺素、游离三碘甲状腺原氨酸、抗甲状腺过氧化物酶或抗甲状腺球蛋白抗体水平没有影响。
在像伊斯坦布尔这样的碘充足地区，吸烟对甲状腺肿发展和甲状腺结节形成没有统计学显著影响。
