Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, United States.
Curr Opin Cell Biol. 2013 Feb;25(1):57-62. doi: 10.1016/j.ceb.2012.10.014. Epub 2012 Nov 10.
The nuclear-cytoskeleton connection influences many aspects of cellular architecture, including nuclear positioning, the stiffness of the global cytoskeleton, and mechanotransduction. Central to all of these processes is the assembly and function of conserved SUN-KASH bridges, or LINC complexes, that span the nuclear envelope. Recent studies provide details of the higher order assembly and targeting of SUN proteins to the inner nuclear membrane. Structural studies characterize SUN-KASH interactions that form the central link of the nuclear-envelope bridge. KASH proteins at the outer nuclear membrane link the nuclear envelope to the cytoskeleton where forces are generated to move nuclei. Significantly, SUN proteins were recently shown to contribute to the progression of laminopathies.
核-细胞骨架的连接影响细胞结构的许多方面，包括核定位、整体细胞骨架的刚性和机械转导。所有这些过程的核心是保守的 SUN-KASH 桥或 LINC 复合物的组装和功能，这些复合物跨越核膜。最近的研究提供了 SUN 蛋白组装到核内膜的更高阶和靶向的细节。结构研究描述了 SUN-KASH 相互作用，这些相互作用构成了核膜桥的中心连接。位于核外膜的 KASH 蛋白将核膜与产生力以移动核的细胞骨架连接起来。重要的是，最近的研究表明 SUN 蛋白有助于层粘连蛋白病的进展。
